Table 1 Genotyping and clinical information of AMD and control RPE, and patient’s skin fibroblasts from which the iPSC-RPE were generated
Donor ID # | Donor age-gender (M: male; F: female) | Clinical diagnosis | CFH (C:risk) | HTRA1 (A:risk) | LOC (T:risk) | Factor B (T:protective) | C2 (C:protective) | Smoking | Cause of death | Time of enucleation (h) | Method of reprogramming | Tissue of origin | Generated iPSC-RPE ID R: RPE-iPSC-RPE F:fibroblasts-iPSC-RPE |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
006 | 72-M | Control | CT | AG | GT | CC | GG | Quit in 1993 | Chronic obstructive pulmonary disease | 12 | Sendai virus | RPE | 6R |
010 | 80-M | Control | CC | AG | GT | CC | GG | Quit in 1984 | Acute myocardial infarction | 9.4 | Sendai virus | RPE | 10R |
025 | 50-M | Control | TT | GG | GG | CC | GG | No | Myocardial infarction | 17 | Sendai virus | RPE | 25R |
009 | 68-F | AMD | TT | GG | GG | TT | GG | 2 ppd for 40 years | Stroke | 3 | Sendai virus | RPE | 9R |
032 | 75-M | AMD | CT | AA | TT | CC | GG | No | Pancreatic cancer | 7 | Sendai virus | RPE | 32R |
Patient ID | Patient age-gender (M: male; F: female) | Clinical diagnosis | CFH (C:risk) | FTRA1 (A:risk) | LOC (T:risk) | Factor B:(A:risk) | C2 (A:risk) | Smoking | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient genotype | |||||||||||||
005BF | 80-F | AMD | CC | AG | GT | AA | CC | Quit in 1982 10 cigarettes pd for 20 years | – | – | Sendai virus | Fibroblasts | 005BF |