Fig. 7

The role of SIRT1/PGC-1α repression in the pathophysiology of AMD. SIRT1 deacetylates and activates PGC-1α. AMPK increases SIRT1 activity and directly phosphorylates and activates PGC-1α. The reduction in SIRT1 activity would reduce deacetylation rate of PGC-1α. Hyperacetylation decreases PGC-1α activity which translates to lower mitochondrial content and activity, lowered mitochondrial respiratory capacity, lowered ROS detoxification and increased ROS production, contributing to the pathophysiology of AMD. Ac acetylation, p phosphorylation