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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration

Fig. 6

Reduced SIRT1 protein levels and PGC-1 expression in AMD-iPSC-RPE. a Quantitative real time PCR showing decreased PGC-1 expression in AMD-iPSC-RPE as compared to normal iPSC-RPE. Graph represents mean ± SE of three independent experiments. Asterisk (****) show statistically significance analyzed by Anova followed by Tukey, p ≤ 0.0001. b Representative western blot image of three independent experiments showing SIRT1 protein levels in iPSC-RPE. B-actin was used as normalization control. c Densitometry of average of three independent western blots showing ≅twofold decrease in SIRT1 protein levels in AMD RPE-iPSC-RPE and AMD Skin-iPSC-RPE as compared to normal RPE-iPSC-RPE. Asterisks (*) in c show significance analyzed by Anova followed by Tukey, p ≤ 0.05

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Journal of Translational Medicine

ISSN: 1479-5876

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