Fig. 5

AMD iPSC-RPE exhibit relevant cellular phenotypes. a–f Representative electron microscopy images of normal (a 25R; c10R; e 25R), AMD-RPE-iPSC-RPE (b 32R; f 9R) and AMD Skin iPSC-RPE (d 005BF) showing diseased phenotypes. Red arrows indicate the observed morphological differences. Higher magnification insets show disintegrated mitochondria (in b 32R), in comparison with the normal mitochondria (in a 25R). M mitochondria, DM disintegrated mitochondria, LD lipid droplets, AP autophagosomes. All scale bars represent 500 nm