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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2

Fig. 7

Schematic diagram illustrating signaling of MALAT1 and its downstream effectors in MCL. a LncRNA MALAT1 recruits PRC2 to target genes through binding to EZH2. Then, CDKN1A/p21 and CDKN1B/p27 expression is epigenetically repressed by H3K27me3. Then, activated CDK1 and CDK2 promotes phosphorylation of EZH2 at T350, resulting in increase binding to MALAT1. b Low expression or knockdown of MALAT1 decrease the recruitment of PRC2 to targeted genes p21 and p27, which inhibit CDKs activities, causing cell cycle arrest and decreased phosphorylation of EZH2 at T350. Finally, EZH2 with low T350 phosphorylation further inhibits its MALAT1-binding activity

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