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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2

Fig. 2

Knockdown of MALAT1 inhibited malignant potential of MCL. a Knockdown of MALAT1 with si-MALAT1(No.1, No.2 and No.3) and nontarget control analyzed by qRT-PCR. b Cell viability assay on MCL cells transfected with si-MALAT1 or si-NC. c Colony formation assay. The number of colonies significantly decreased, and the size of individual colonies were significantly reduced in MALAT1 knockdown Mino cells. d Apoptosis in MCL cells transfected with si-MALAT1 or si-NC was detected by flow cytometry after annexin V/PI staining. e Cell cycle analysis by flow cytometry. Ratio of percentage of cells in S phase to G1 phase was significantly decreased in MALAT1 knockdown MCL cells (Mino and Jeko-1). Data are representative of three independent experiments and represent the mean ± SD

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