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Table 1 Haemodynamic measurements and blood gas analyses

From: Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function?

Variable

Normothermic E-CPR group

Hypothermic E-CPR group

Post-arrest, difference between groups

Baseline

Post-arrest

Baseline

Post-arrest

MD (95% CI)

p value

a. Haemodynamic measurements

 HR (beats/min)

88 ± 23

152 ± 31*

101 ± 26

148 ± 33*

−4 (−35 27)

p = 0.79

 MAP (mmHg)

84.2 ± 12.0

73.6 ± 16.1

93.1 ± 14.4

65.6 ± 14.1*

−8.1 (−22.6 6.5)

p = 0.26

 CVP (mmHg)

5.7 ± 2.8

6.1 ± 3.1

6.9 ± 1.6

8.7 ± 2.9

2.6 (−0.3 5.5)

p = 0.078

 LVPmax (mmHg)

99.6 ± 7.0

91.0 ± 13.5

107.7 ± 13.2

86.4 ± 14.8*

−4.6 (−18.4 9.2)

p = 0.49

 EDP (mmHg)

14.0 ± 4.7

14.9 ± 2.4

12.9 ± 3.7

11.7 ± 3.7

−3.2 (−6.3 −0.1)

p = 0.041

 dP/dtmax (mmHg/s)

1427 ± 207

1963 ± 557

1786 ± 414

2398 ± 1466

435 (−663 1533)

p = 0.41

 dP/dtmin (mmHg/s)

−2112 ± 270

−1683 ± 404

−2225 ± 315

−1792 ± 832

−109 (−755 537)

p = 0.73

 tau (ms)

32.4 ± 3.0

33.3 ± 6.8

32.3 ± 3.2

28.5 ± 8.3

0.68 (−5.7 7.1)

p = 0.19

 EDP/EDV (mmHg/ml)

0.14 ± 0.04

0.16 ± 0.03

0.14 ± 0.04

0.14 ± 0.04

−0.02 (−0.06 0.01)

p = 0.15

 Ea (mmHg/ml)

1.08 ± 0.25

1.65 ± 0.44*

1.16 ± 0.35

1.68 ± 0.72*

0.03 (−0.56 0.62)

p = 0.91

b. Blood gas analyses

 Hb (g/dl)

8.3 ± 0.9

8.1 ± 0.7*

8.7 ± 0.8

7.8 ± 1.1*

−0.3 (−1.3 0.6)

p = 0.45

 PaO2 (kPa)

22.5 ± 1.9

20.6 ± 3.7

22.6 ± 1.4

21.5 ± 2.4

0.90 (−2.1 −3.9)

p = 0.53

 PaCO2 (kPa)

5.4 ± 0.7

5.4 ± 0.3

4.9 ± 0.4

4.9 ± 0.4

−0.45 (−0.82 −0.08)

p = 0.019

 pH

7.49 ± 0.04

7.47 ± 0.03

7.51 ± 0.05

7.48 ± 0.05

−0.01 (−0.03 0.06)

p = 0.63

 BaseExcess (mmol/l)

6.77 ± 1.15

4.97 ± 1.82*

6.23 ± 2.38

3.56 ± 2.12*

−1.41 (−3.39 0.56)

p = 0.15

 Lactate (mmol/l)

0.85 ± 0.19

1.28 ± 0.54*

1.34 ± 0.85

2.8 ± 1.57*

1.52 (0.36 2.68)

p = 0.013

 Ca2+ (mmol/l)

1.30 ± 0.06

1.27 ± 0.06

1.25 ± 0.06

1.27 ± 0.06

0.003 (−0.06 0.06)

p = 0.91

 SvO2 (%)

65.7 ± 14.8

42.4 ± 8.7*

68.4 ± 7.4

42.3 ± 13.4*

−0.2 (−11.2 −10.9)

p = 0.98

  1. Values are expressed as mean ± standard deviation. Comparison post-arrest to baseline within group by paired student’s t-test
  2. Post-arrest comparison of groups by unpaired two-sample student’s t-test. MD mean difference, CI 95% confidence interval
  3. HR heart rate, MAP mean aortic blood pressure, CVP central venous pressure, LVP max systolic left ventricular pressure maximum, EDP end-diastolic pressure, dP/dt max maximum left ventricular pressure first time derivate, dP/dt min minimum left ventricular pressure first time derivate, tau isovolumetric relaxation constant, Ea arterial elastance, S V O 2 mixed venous oxygen saturation
  4. * p ≤ 0.05
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Journal of Translational Medicine

ISSN: 1479-5876

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