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Table 1 Haemodynamic measurements and blood gas analyses

From: Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function?

Variable Normothermic E-CPR group Hypothermic E-CPR group Post-arrest, difference between groups
Baseline Post-arrest Baseline Post-arrest MD (95% CI) p value
a. Haemodynamic measurements
 HR (beats/min) 88 ± 23 152 ± 31* 101 ± 26 148 ± 33* −4 (−35 27) p = 0.79
 MAP (mmHg) 84.2 ± 12.0 73.6 ± 16.1 93.1 ± 14.4 65.6 ± 14.1* −8.1 (−22.6 6.5) p = 0.26
 CVP (mmHg) 5.7 ± 2.8 6.1 ± 3.1 6.9 ± 1.6 8.7 ± 2.9 2.6 (−0.3 5.5) p = 0.078
 LVPmax (mmHg) 99.6 ± 7.0 91.0 ± 13.5 107.7 ± 13.2 86.4 ± 14.8* −4.6 (−18.4 9.2) p = 0.49
 EDP (mmHg) 14.0 ± 4.7 14.9 ± 2.4 12.9 ± 3.7 11.7 ± 3.7 −3.2 (−6.3 −0.1) p = 0.041
 dP/dtmax (mmHg/s) 1427 ± 207 1963 ± 557 1786 ± 414 2398 ± 1466 435 (−663 1533) p = 0.41
 dP/dtmin (mmHg/s) −2112 ± 270 −1683 ± 404 −2225 ± 315 −1792 ± 832 −109 (−755 537) p = 0.73
 tau (ms) 32.4 ± 3.0 33.3 ± 6.8 32.3 ± 3.2 28.5 ± 8.3 0.68 (−5.7 7.1) p = 0.19
 EDP/EDV (mmHg/ml) 0.14 ± 0.04 0.16 ± 0.03 0.14 ± 0.04 0.14 ± 0.04 −0.02 (−0.06 0.01) p = 0.15
 Ea (mmHg/ml) 1.08 ± 0.25 1.65 ± 0.44* 1.16 ± 0.35 1.68 ± 0.72* 0.03 (−0.56 0.62) p = 0.91
b. Blood gas analyses
 Hb (g/dl) 8.3 ± 0.9 8.1 ± 0.7* 8.7 ± 0.8 7.8 ± 1.1* −0.3 (−1.3 0.6) p = 0.45
 PaO2 (kPa) 22.5 ± 1.9 20.6 ± 3.7 22.6 ± 1.4 21.5 ± 2.4 0.90 (−2.1 −3.9) p = 0.53
 PaCO2 (kPa) 5.4 ± 0.7 5.4 ± 0.3 4.9 ± 0.4 4.9 ± 0.4 −0.45 (−0.82 −0.08) p = 0.019
 pH 7.49 ± 0.04 7.47 ± 0.03 7.51 ± 0.05 7.48 ± 0.05 −0.01 (−0.03 0.06) p = 0.63
 BaseExcess (mmol/l) 6.77 ± 1.15 4.97 ± 1.82* 6.23 ± 2.38 3.56 ± 2.12* −1.41 (−3.39 0.56) p = 0.15
 Lactate (mmol/l) 0.85 ± 0.19 1.28 ± 0.54* 1.34 ± 0.85 2.8 ± 1.57* 1.52 (0.36 2.68) p = 0.013
 Ca2+ (mmol/l) 1.30 ± 0.06 1.27 ± 0.06 1.25 ± 0.06 1.27 ± 0.06 0.003 (−0.06 0.06) p = 0.91
 SvO2 (%) 65.7 ± 14.8 42.4 ± 8.7* 68.4 ± 7.4 42.3 ± 13.4* −0.2 (−11.2 −10.9) p = 0.98
  1. Values are expressed as mean ± standard deviation. Comparison post-arrest to baseline within group by paired student’s t-test
  2. Post-arrest comparison of groups by unpaired two-sample student’s t-test. MD mean difference, CI 95% confidence interval
  3. HR heart rate, MAP mean aortic blood pressure, CVP central venous pressure, LVP max systolic left ventricular pressure maximum, EDP end-diastolic pressure, dP/dt max maximum left ventricular pressure first time derivate, dP/dt min minimum left ventricular pressure first time derivate, tau isovolumetric relaxation constant, Ea arterial elastance, S V O 2 mixed venous oxygen saturation
  4. * p ≤ 0.05