Table 4 The inflammatory signaling pathways and related gene transcripts affected by daily injection of HPG solution compared to Sham

B cell development (0.00016)

HLA-DRA, HLA-DRB5, IL7, IL7R, PTPRC, SPN

–

Complement (0.001)

C2, C3, C6, C4BPA, C5AR1, CFD, ITGB2

–

Cross talk between DCs and NK cells (0.0016)

ACTG2, HLA-DRA, HLA-DRB5, CD83

IL6, MIBC, FSCN1, FSCN2, CAMK2D, ACTG2

Granulocyte adhesion and diapedesis (0.0032)

C5AR1, CCL21, CXCL14, EZR, ITGA2, ITGB2, MMP11, VCAM1

CCL2, CXCL2, CXCL10, CXCR4, THY1

Agranulocyte adhesion and diapedesis (0.004)

ACTG2, VCAM1, EZR, ITGB2, C5AR1, ITGA2, MMP11, CXCL14, CCL21, AOC3

CCL2, CXCL2, CXCL10, CXCR4

ICOS/ICOSL signaling in Th cells (0.01)

CD247, CD3G, HLA-DRA, HLA-DRB5, ICOSLG, IKBKE, ITK, PTPRC

Calm1, CAMK2D

Antigen presentation pathway (0.01)

CIITA, CD74, HLA-DRA, HLA-DRB5

Nur 77 signaling in T cells (0.0316)

CD247, CD3G, HLA-DRA, HLA-DRB5

Calm1

Acute phase response signaling (0.0316)

C2, SERPINA3, IKBKE, ITIH4, C3, FGG, AGT, RBP4, C4BPA

IL6, FOS, MAPK11

CD28 signaling in Th cells (0.0316)

HLA-DRA, HLA-DRB5, PTPRC, CD247, CD3G, IKBKE, ITK

Calm1, FOS

IL-17 signaling in fibroblast (0.0316)

IKBKE

IL6, FOS, MAPK11

Role of hypercytokinemia/hyperchemokinemia in the pathogenesis (0.3162, NS)

–

CCCL10, IL6

IL-10 signaling (0.2512, NS)

IKBKE

IL6, FOS, MAPK11

Differential regulation of cytokine production in MΦ and Th cells (0.5012, NS)

–

IL6

Inhibition of matrix metalloproteinase (0.0631, NS)

LRP1, MMP11, SDC1, THBS2

–

TREM1 signaling (0.5012, NS)

CD83, CIITA

IL6

IL-6 signaling (0.5012, NS)

IKBKE

IL6, FOS, MAPK11, CSNK2A2

Toll-like receptor signaling (1.0, NS)

–

FOS, MAPK11

MIF-mediated glucocortical regulation (0.1259, NS)

CD74, PLA2G2A, PLA2G5

–

MIF regulation of innate immunity (0.0794, NS)

CD74, PLA2G2A, PLA2G5

FOS

HMGB1 signaling (1.0, NS)

VCAM1

IL6, FOS, MAPK11