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Table 2 The inflammatory signaling pathways and related gene transcripts affected by daily injection of electrolyte solution (Control) compared to Sham

From: Hyperbranched polyglycerol is superior to glucose for long-term preservation of peritoneal membrane in a rat model of chronic peritoneal dialysis

Signaling pathways (p value)

Up regulated genes

Down regulated genes

Complement (1 × 10 6)

C2, C3, C6, C4BPA, CFD, ITGB2, ITGAM, ITGAX

C7

B cell development (6 × 10 6)

HLA-DRA, HLA-DRB5, HLA-DQB1, IL7, IL7R, PTPRC, SPN

CD28 signaling in Th cells (1 × 10 5)

HLA-DRA, HLA-DRB5, HLA-DQB1, CD247, CD3E, CD3G, GRAP2, PAK1, PTPRC, VAV1

Calm1, FOS, PIK3C2G, PIK3R3

ICOs/ICOSL signaling in Th cells (1.3 × 10 5)

CD247, CD3E, CD3G, GRAP2, HLA-DQB1, HLA-DRA, HLA-DRB5, PTPRC, VAV1

Calm1, CAMK2D, PIK3C2G, PIK3R3

Nur 77 signaling in T cells (5 × 10 5)

CD247, CD3G, HLA-DRA, HLA-DRB5, HLA-DQB1, CD3E

Calm1, CASP3

Agranulocyte adhesion and diapedesis (0.0001)

ACTC1, AOC3, CCL4, CCL9, EZR, IL18, ITGB2, MYH3

CCL20, CD34, CLDN5, CXCL2, CXCR4, ICAM2, MMP27

Granulocyte adhesion and diapedesis (0.00013)

CCL4, CCL9, EZR, IL18, ITGAM, ITGB2

CCL20, CLDN5, CXCL2, CXCR4, ICAM2, IL1R2, MMP27

Cross talk between DCs and NK cells (0.001)

ACTG2, HLA-DRA, HLA-DRB5, IL18

IL6, MIBC, FSCN1, CAMK2D, ACTC1, TNFSF10

Antigen presentation pathway (0.001)

CIITA, CD74, HLA-DRA, HLA-DRB5

Acute phase response signaling (0.001)

AGT, C2, C3, C4BPA, IL18, KLKB1, RBP4, SERPINA3

FOS, IL6, PIK3R3, VWF

Role of hypercytokinemia/hyperchemokinemia in the pathogenesis (0.003162)

CCL4, IL18

IL6

TREM1 signaling (0.0631, NS)

CIITA, IL18, ITGAX, TLR11

IL6

IL-10 signaling (0.0631, NS)

IL18, IL10RA

FOS, IL6, IL1R2

Differential regulation of cytokine production in MΦ and Th cell (0.1, NS)

CCL4

IL6

IL-6 signaling (0.1259, NS)

IL18

IL6, FOS, IL1R2, PIK3C2G, PIK3R3

HMGB1 signaling (0.1259, NS)

IL18

IL6, FOS, PIK3C2G, PIK3R3, RHOJ

Inhibition of matrix metalloproteinase (0.2512, NS)

THBS2

MMP27

IL-17 signaling in fibroblast (0.2512, NS)

 

IL6, FOS

MIF regulation of innate immunity (0.3162, NS)

CD74

FOS

MIF-mediated glucocortical regulation (0.5012, NS)

CD74

Toll-like receptor signaling (1.0, NS)

IL18

FOS

  1. The affected signaling pathways were ranked from the most (top) to the least significant (bottom) based on the p value
  2. DC dendritic cell, NK natural killer, Th T helper, macrophage, ICOS inducible costimulator, ICOSL inducible costimulatory ligand, TREM1 triggering receptor expressed on myeloid cells 1, MIF macrophage migration inhibitory factor, HMGB1 high mobility group box 1, NS not significant