Table 1 The p values (as a function) of affected inflammatory signaling pathways between Control, PYS and HPG compared to Sham

B cell development (22)

6.3 × 10⁻⁶ (+7)

0.001 (+5)

0.0002 (+6)

Complement (34)

1 × 10⁻⁶ (+8, −1)

1 × 10⁻⁵ (+8)

0.001 (+7)

Cross talk between DCs and NK cells (68)

0.001 (+4, −6)

0.0025 (+4, −4)

0.0016 (+5, −6)

Granulocyte adhesion and diapedesis (145)

0.0001 (+6, −7)

1 × 10⁻¹¹ (+18, −8)

0.0032 (+8, −5)

Agranulocyte adhesion and diapedesis (154)

0.0001 (+8, −7)

1 × 10⁻¹⁰ (+18, +7)

0.004 (+10, −4)

ICOS/ICOSL signaling in Th cells (96)

1.3 × 10⁻⁵ (+9, −4)

0.0032 (+6, −3)

0.01 (+8, −2)

Antigen presentation pathway (22)

0.001 (+4)

0.0032 (+4)

0.01 (+4)

Nur 77 signaling in T cells (43)

5 × 10⁻⁵ (+6, −2)

NS (+2, −2)

0.0316 (+4, −1)

Acute phase response signaling (157)

0.001 (+8, −4)

1 × 10⁻⁶ (+17, −3)

0.0316 (+9, −3)

CD28 signaling in Th cells (106)

1 × 10⁻⁵ (+10, −4)

0.0126 (+7, −2)

0.0316 (+7, −2)

IL-17 signaling in fibroblast (23)

NS (−2)

0.0501 (+3, −1)

0.0315 (+1, −3)

Role of hypercytokinemia/hyperchemokinemia in the pathogenesis (27)

0.00316 (+2, −1)

3.2 × 10⁻⁸ (+7, −2)

NS (−2)

IL-10 signaling (65)

NS (+2, −3)

1 × 10⁻⁵ (+8, −3)

NS (+1, −3)

Differential regulation of cytokine production in MΦ and Th cell (15)

NS (+1, −1)

0.0001 (+5)

NS (−1)

Inhibition of matrix metalloproteinase (36)

NS (+1, −1)

0.002 (+4)

NS (+4)

TREM1 signaling (67)

NS (+4, −1)

0.0025 (+7, −1)

NS (+2, −1)

IL-6 signaling (114)

NS (+1, −5)

0.01 (+7, −3)

NS (+1, −4)

Toll-like receptor signaling (71)

NS (+1, −1)

0.0126 (+6, −1)

NS (−2)

MIF-mediated glucocortical regulation (29)

NS (+1)

0.0501 (+4)

NS (+3)

MIF regulation of innate immunity (73)

NS (+1)

0.0501 (+4)

NS (+3, −1)

HMGB1 signaling (112)

NS (+1, −5)

0.0501 (+6, −2)

NS (+1, −3)