Skip to main content
Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Colonization of xenograft tumors by oncolytic vaccinia virus (VACV) results in enhanced tumor killing due to the involvement of myeloid cells

Fig. 3

Targeting different myeloid cell subsets. a A representative FACS dot plot shows the results of depletion by mAb 1A8 or clodrosome. iNOS+ neutrophilic (Neu) and F4/80+ monocytic cells (Mac) were depleted to different extents 48 h. post-depletion. b, c Depletion or blocking of iNOS+ Neutrophilic cells showed a similar result on tumor growth between days 7 and 10 post-VACV infection. The effect of single or multiple-depletion of iNOS+ neutrophilic (Neu) versus F4/80+ monocytic cells (Mac) on tumor size in b was compared to the iNOS-blocking agent, L-NIL in c. d, e Monitoring of tumor growth by fluorescence imaging. Carestream imaging system performed visualization of viral tumor colonization and the signal intensity was quantified as mean RFU per tumor area. The results shown are from one of two independent experiments that produced similar results

Back to article page