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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment

Fig. 2

The MSC markers Gremlin-1 and CD90 are co-localized in the TM of patients with OCSCC (oral tongue). High power resolution confocal images from representative sections of 2 (T1 and T2) human OCSCC specimens (AH) and adjacent normal (N) tissue (IL) are shown. Gremlin-1+ cells (red; A, F) and CD90+ (blue; C, G) are identified in the TM and to a lesser extent adjacent normal tissue (J, K). When the photomicrographs are merged, co-localization of gremlin-1+ and CD90+ cells yields a magenta color (D, H). Additional, Z-stack image analysis with orthogonal sectioning (D, white arrow) demonstrates gremlin-1+/CD90+ cells (magenta color) in both the x and y planes

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