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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment

Fig. 1

MSCs reside in the OPSCC (human tonsil) tumor stromal microenvironment. The black arrows denote the tumor microenvironment (TM). Representative immunohistological sections of human OPSCC demonstrates the presence of a distinct population of gremlin-1+ MSCs in the TM (ac). The black square denotes areas viewed at higher magnification. Cells positive for the myofibroblast/CAF marker, α-SMA+ , were also present within the TM (df). A small population of CD14+ lymphocytes are seen at higher power magnification, representing cells of hematopoietic lineage (gi). The above photomicrographs are serial sections (4 μm thickness)

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