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Table 3 Association of thyroid hormones with rapid eGFR decline during follow-up

From: Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation

 

Case/number (%)

Model 1

Model 2

Model 3

Serum FT4

 Tertile 1

40/699 (5.7)

1.00

1.00

1.00

 Tertile 2

56/701 (8.0)

1.40 (0.92–2.14)

1.38 (0.89–2.12)

1.40 (0.91–2.16)

 Tertile 3

69/703 (9.8)

1.72 (1.15–2.59)

1.61 (1.06–2.45)

1.64 (1.07–2.50)

 P for trend

0.0004

0.009

0.03

0.02

 Each 1-pmol/l increase in FT4

165/2103 (7.9)

1.12 (1.05–1.21)

1.10 (1.02–1.18)

1.10 (1.03–1.18)

Serum FT3

 Tertile 1

55/687 (8.0)

1.00

1.00

1.00

 Tertile 2

69/712 (9.7)

1.29 (0.89–1.87)

1.35 (0.91–1.99)

1.36 (0.92–2.00)

 Tertile 3

41/704 (5.8)

0.79 (0.51–1.21)

0.84 (0.54–1.30)

0.83 (0.53–1.30)

 P for trend

0.025

0.33

0.50

0.49

 Each 1-pmol/l increase in FT3

165/2103 (7.9)

1.17 (0.95–1.44)

1.14 (0.93–1.40)

1.13 (0.92–1.39)

Serum TSH

 Tertile 1

63/700 (9.0)

1.00

1.00

1.00

 Tertile 2

53/700 (7.6)

0.77 (0.53–1.14)

0.85 (0.57–1.26)

0.85 (0.57–1.26)

 Tertile 3

49/703 (7.0)

0.67 (0.44–0.99)

0.75 (0.50–1.15)

0.74 (0.49–1.14)

 P for trend

0.35

0.046

0.18

0.17

 Each 1-μIU/ml increase in TSH

165/2103 (7.9)

0.97 (0.88–1.08)

1.00 (0.92–1.08)

1.00 (0.92–1.08)

  1. Model 1: adjusted for age, sex, BMI at baseline
  2. Model 2: further adjusted for triglyceride, HDL-c, diabetes and hypertension status, current smoking and drinking status, use of antihypertensive drugs, use of antidiabetic drugs, eGFR at baseline
  3. Model 3: Further adjusted for TPOAb, TGAb at baseline
  4. P for trend values for percentages of rapid eGFR decline are calculated by using Cochran–Mantel–Haenszel (CMH) method
  5. Data are odds ratios (95% confidence intervals)
  6. BMI body mass index, eGFR estimated glomerular filtration rate, FT3 free triiodothyronine, FT4 free thyroxine, HDL-c high-density lipoprotein cholesterol, TSH thyroid-stimulating hormone, TPOAb thyroid peroxidase antibody, TGAb thyroglobulin antibody