Fig. 1

Survival, disease score and cytokine serum concentrations of Aqp5-knockout and wild type mice after intraperitoneal lipopolysaccharide injection. a Kaplan–Meier plot of overall survival of Aqp5-KO and WT mice after i.p. application of 20 mg/kg bodyweight lipopolysaccharide (LPS) or saline (NaCl) (n = 18 per group, saline: n = 8). 56% (10/18) of the Aqp5-KO mice but only 22% (4/18) of the WT mice survived for 7 days (p = 0.04). b Disease score recorded at different time points after LPS injection. WT mice showed a significantly increased disease score compared to Aqp5-KO mice (p = 0.028) after 96 h. c, d Interleukin-10 and tumor necrosis factor alpha serum concentrations of Aqp5-KO and WT mice measured 4.5 and 24 h after intraperitoneal LPS injection. IL-10 concentrations (c, n = 7, 9, 10, 9); TNF-alpha concentration (d, n = 13, 12, 12, 11) No differences were detected in concentrations of these cytokines between Aqp5-KO and WT mice. p ≫ 0.05 for all comparisons between Aqp5-KO and WT mice. b–d Data are shown as boxplots (min to max)