Fig. 2

Biological networks of healthy (left panel) and diseased (right panel) individuals. Biological components in healthy individuals are represented as green nodes in a network. Pathological perturbation, represented by red nodes that lead to morbidity, can occur at different stages of the regulation of key components: a presence and absence of key component (green for presence and red for absence), b mis-regulated gene expression, leading to over- or under-expression (node sizes represent expression levels), c absence or erroneous interactions with interacting partners (dotted lines represent erroneous interactions), d mis-regulated directions (mis-directed arrows), or e strengths of interactions (thicknesses of arrows and accompanying numbers denote interaction strengths)