Fig. 4

Histological study of MRD. a Primary tumor sections from a control mouse (PBS group): NHL-B histology is observed and corresponds to a diffuse infiltration by centrocytes and centroblasts with a starry sky pattern, due to high proliferation rate. b Retroperitoneal sections from a mouse where NHL disease persists post-chemotherapy: similar histology of primary tumor is observed. c Liver sections from a mouse with complete remission: typical healthy hepatic architecture with the centrilobular veins and hepatic sinusoids is observed. d Tumor-infiltrated liver sections from a mouse where NHL disease persists post-chemotherapy: infiltrating tumor cells are observed in portal field. e Spleen section from mouse with complete remission: normal architecture with the white and red pulp is observed