TY - JOUR AU - Selmi, Valentina AU - Loriga, Beatrice AU - Vitali, Luca AU - Carlucci, Martina AU - Di Filippo, Alessandro AU - Carta, Giulio AU - Sgambati, Eleonora AU - Tofani, Lorenzo AU - De Gaudio, Angelo Raffaele AU - Novelli, Andrea AU - Adembri, Chiara PY - 2016 DA - 2016/11/15 TI - Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat JO - Journal of Translational Medicine SP - 316 VL - 14 IS - 1 AB - Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics–pharmacodynamics (PK/PD) of ceftriaxone (CTX), an extensively protein-bound 3rd generation cephalosporin, is altered during early sepsis and whether an increase in urinary loss of bound-CTX, due to GFB alteration, can occur in this condition. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-016-1072-9 DO - 10.1186/s12967-016-1072-9 ID - Selmi2016 ER -