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Table 1 Cytokine profile at endpoint in arthritis-affected DA rats with and without periodontitis

From: Effects by periodontitis on pristane-induced arthritis in rats

 

PA (n = 9)

A (n = 12)

P value

TNF-α

110 (3–182)

75 (3–211)

NS

IL-1α

10,608 (2044–18,703)

10,299 (2191–29,782)

NS

IL-1β

20,842 (1170–45,925)

14,170 (1636–41,213)

NS

IL-2

1291 (532–2158)

1046 (282–2283)

NS

IL-4

723 (101–1223)

583 (124–1259)

NS

IL-5

566 (179–798)

469 (224–807)

NS

IL-7

3072 (418–4674)

2540 (526–7174)

NS

IL-10

899 (243–1274)

770 (205–1965)

NS

IL-12

985 (93–1939)

680 (120–1614)

NS

IL-13

243 (14–494)

170 (6–449)

NS

IL-17

214 (39–360)

173 (55–408)

NS

IL-18

2268 (1057–3765)

1449 (445–2673)

NS

EPO

780 (436–1079)

536 (145–1231)

NS

GM-CSF

259 (2–778)

127 (2–653)

NS

M-CSF

766 (578–1073)

753 (658–938)

NS

GRO/KC

214 (133–294)

150 (66–247)

NS

MIP-3α

227 (49–368)

175 (53–375)

NS

RANTES

1028 (402–1628)

735 (356–1280)

NS

VEGF

149 (23–286)

102 (20–246)

NS

MCP-1

4407 (1735–7249)

3634 (2499–4867)

NS

  1. Mean (range) plasma concentrations (pg/ml) of cytokines (TNF-α, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-7, IL-10, IL-12, IL-13, IL-17, IL-18, EPO, GM-CSF, M-CSF, GRO/KC, MIP-3α, RANTES, VEGF and MCP-1) in arthritis rats with and without periodontitis, collected at endpoint
  2. DA Dark Agouti, PA rats with experimental periodontitis and pristane-induced arthritis, A rats with pristane-induced arthritis without periodontitis, NS not significant
  3. * P < 0.05 was considered statistically significant