Putrescine treatment reverses α-tocopherol-induced desynchronization of polyamine and retinoid metabolism during rat liver regeneration

Table 1 Liver levels of ornithine and citrulline in animals subjected to PH and treated with α-tocopherol and/or putrescine

Treatment	Ornithine	Citrulline	Ornithine/citrulline ratio
Sham (control)	378 ± 57	529 ± 63	0.71 ± 0.09
PH + vehicle
6 h post-PH	257 ± 26	438 ± 53	0.59 ± 0.06
12 h post-PH	345 ± 41	575 ± 81	0.60 ± 0.07
24 h post-PH	551 ± 77	631 ± 101	0.87 ± 0.12
48 h post-PH	515 ± 67	746 ± 104	0.69 ± 0.10
72 h post-PH	458 ± 51	309 ± 37*	1.48 ± 0.23*
PH + VE
6 h post-PH	513 ± 62**	616 ± 80	0.83 ± 0.10
12 h post-PH	761 ± 107^,*	614 ± 92	1.24 ± 0.18^,*
24 h post-PH	569 ± 91	584 ± 99	0.97 ± 0.16
48 h post-PH	608 ± 85**	507 ± 76	1.20 ± 0.17^,*
72 h post-PH	746 ± 90^,*	415 ± 54	1.80 ± 0.23^,*
PH + Putrescine
6 h post-PH	468 ± 80**	440 ± 52	1.06 ± 0.15**
12 h post-PH	510 ± 77	185 ± 24^,*	2.76 ± 0.39^,*
24 h post-PH	548 ± 71	601 ± 90	0.91 ± 0.13
48 h post-PH	705 ± 78*	805 ± 137	0.88 ± 0.12
72 h post-PH	488 ± 44	303 ± 39*	1.48 ± 0.16*
PH + VE + Putres
6 h post-PH	983 ± 118^,*	898 ± 135**	1.04 ± 0.14**
12 h post-PH	587 ± 82**	257 ± 41^,*	2.28 ± 0.34^,*
24 h post-PH	674 ± 106*	690 ± 97	0.98 ± 0.15
48 h post-PH	755 ± 78^,*	938 ± 131*	0.80 ± 0.10
72 h post-PH	535 ± 55	217 ± 27*	2.47 ± 0.28^,*

Results are the mean ± SE of 5 individual observations by experimental point and expressed by gram of liver
PH partial hepatectomy, VE α-tocopherol, and Putres putrescine. Statistical significance, as indicated in *

ISSN: 1479-5876