Table 2 Efficacy of ALK inhibitors according to ALK fusion variants
From: Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants
Total (N = 52) | EML4-ALK variant 1 (N = 20) | EML4-ALK variant 2 (N = 3) | EML4-ALK variant 3a/b (N = 10) | Non-EML4 variants (N = 19) | P value | |
|---|---|---|---|---|---|---|
First-line, platinum-based CTx, N (%) | 40 (76.9) | 17 (85.0) | 1 (33.3) | 9 (90.0) | 13 (68.4) | 0.979 |
PR | 10 (25.0) | 4 (23.5) | 0 (0.0) | 3 (33.3) | 3 (23.1) | |
SD | 20 (50.0) | 9 (52.9) | 1 (100.0) | 4 (44.4) | 6 (46.2) | |
PD | 10 (25.0) | 4 (23.5) | 0 (0.0) | 2 (22.2) | 4 (30.8) | |
ORR, % | 25.0 | 23.5 | 0.0 | 33.3 | 23.1 | 0.853 |
DCR, % | 75.0 | 76.5 | 100.0 | 77.8 | 69.2 | 0.791 |
Received pemetrexed, any line, N (%) | 35 (67.3) | 17 (85.0) | 1 (33.3) | 6 (60.0) | 11 (57.9) | 0.591 |
PR | 7 (20.0) | 2 (11.8) | 0 (0.0) | 3 (50.0) | 2 (18.2) | |
SD | 25 (71.4) | 13 (76.5) | 1 (100.0) | 3 (50.0) | 8 (72.7) | |
PD | 3 (8.6) | 2 (11.8) | 0 (0.0) | 0 (0.0) | 1 (9.1) | |
ORR, % | 20.0 | 11.8 | 0.0 | 50.0 | 18.2 | 0.291 |
DCR, % | 91.4 | 88.2 | 100.0 | 100.0 | 90.9 | 1.000 |
Received Crizotinib, N (%) | 32 (61.5) | 10 (50.0) | 2 (66.7) | 8 (80.0) | 12 (63.2) | 0.134 |
PR | 17 (53.1) | 3 (30.0) | 2 (100.0) | 4 (50.0) | 8 (66.7) | |
SD | 10 (31.3) | 5 (50.0) | 0 (0.0) | 1 (12.5) | 4 (33.3) | |
PD | 5 (15.6) | 2 (20.0) | 0 (0.0) | 3 (37.5) | 0 (0.0) | |
ORR, % | 53.1 | 30.0 | 100.0 | 50.0 | 66.7 | 0.191 |
DCR, % | 84.4 | 80.0 | 100.0 | 62.5 | 100.0 | 0.109 |
Received Ceritinib, N (%) | 14 (26.9) | 5 (25.0) | 1 (33.3) | 3 (30.0) | 5 (26.3) | 0.723 |
CR | 1 (7.1) | 0 (0.0) | 1 (100.0) | 0 (0.0) | 0 (0.0) | |
PR | 7 (50.0) | 2 (40.0) | 0 (0.0) | 2 (66.7) | 3 (60.0) | |
SD | 4 (28.6) | 2 (40.0) | 0 (0.0) | 1 (33.3) | 1 (20.0) | |
PD | 1 (7.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (20.0) | |
ORR, % | 57.1 | 50.0 | 100.0 | 66.7 | 62.5 | NA |
DCR, % | 85.7 | 100.0 | 100.0 | 100.0 | 80.0 | NA |
Received Alectinib, N (%) | 2 (3.8) | 0 (0.0) | 0 (0.0) | 1 (10.0) | 1 (5.3) | NA |
PR | 2 (100.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) | 1 (100.0) |