Skip to main content
Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Angiopoietin-2 impairs collateral artery growth associated with the suppression of the infiltration of macrophages in mouse hindlimb ischaemia

Fig. 1

r-Ang-2 impaired blood flow perfusion during ischaemia. a Representative laser-Doppler images of the plantar foot at the indicated time points after femoral artery ligation. “Pre” and “Post” are immediately before and after surgery, respectively. b The mean blood flow ratio of ischaemic to non-ischaemic hindlimb foot pads for all animals at indicated time points (n = 6/group; *P < 0.05 vs. the r-Ang-2 groupat 5 and 7 days). c Representative laser-Doppler images of the adductor region at the indicated time points after femoral artery ligation. “Pre” and “Post” are immediately before and after surgery, respectively. Outlined areas shown the regions of interest. d The mean blood flow ratio in ischaemic to non-ischaemic hindlimb footpads for all animals at the indicated time points (n = 6/group; *P < 0.05 vs. r-Ang-2 group at 5 and 7 days). e Representative images of PECAM-1+ capillaries in ischaemic gastrocnemius muscles 7 days after femoral artery ligation. Scale bars 100 μm. f Mean capillary density in ischaemic gastrocnemius muscles assessed by PECAM-1 immunostaining. g Representative images of collateral arterioles in ischaemic adductor muscles, assessed using H&E staining. h The ratio of mean arteriole diameter in Ang-2 group to vehicle in ischaemic adductor muscles (n = 6/group; *P < 0.05 vs. vehicle)

Back to article page