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Table 3 Statistical correlation of gene mutations with prognostic parameters

From: Prognostic impact of KRAS, NRAS, BRAF, and PIK3CA mutations in primary colorectal carcinomas: a population-based study

Mutated gene Risk ratio 95 % CI p
Partial survival (from metastatic disease onset to death or last control)
 KRAS 1.257 0.628–1.739 0.4906
 NRAS 1.634 1.018–2.712 0.0763
 All RAS 1.345 0.968–2.158 0.0924
 BRAF 3.214 1.387–7.445 0.0064
 All RAS + BRAF 1.733 0.997–2.994 0.0511
 PIK3CA 1.403 0.877–1.479 0.1365
Overall survival (from disease diagnosis to death or last control)
 KRAS 1.219 0.983–1.512 0.0703
 NRAS 1.052 0.612–1.810 0.8522
 All RAS 1.108 0.932–1.316 0.2432
 BRAF 4.120 2.491–6.812 <0.001
 All RAS + BRAF 1.878 1.238–3.996 0.0394
 PIK3CA 0.934 0.711–1.226 0.6246
Time to progression as metastatic disease (from disease diagnosis to first metastasis)
 KRAS 1.077 0.843–1.677 0.1508
 NRAS 1.154 0.853–1.851 0.1006
 All RAS 1.277 1.025–2.371 0.0943
 BRAF 2.972 1.261–6.332 0.0091
 All RAS + BRAF 2.217 1.125–4.371 0.0214
 PIK3CA 0.964 0.691–1.346 0.8337