TY - JOUR AU - Jemal, A. AU - Center, M. M. AU - DeSantis, C. PY - 2010 DA - 2010// TI - Global patterns of cancer incidence and mortality rates and trends JO - Cancer Epidemiol Biomarkers Prev. VL - 19 UR - https://doi.org/10.1158/1055-9965.EPI-10-0437 DO - 10.1158/1055-9965.EPI-10-0437 ID - Jemal2010 ER - TY - STD TI - SEER cancer statistics factsheets: colon and rectum cancer. Bethesda: National Cancer Institute; http://seer.cancer.gov/statfacts/html/colorect.html. Accessed 20 May 2016. UR - http://seer.cancer.gov/statfacts/html/colorect.html ID - ref2 ER - TY - JOUR AU - Fearon, E. R. AU - Vogelstein, B. PY - 1990 DA - 1990// TI - A genetic model for colorectal tumorigenesis JO - Cell VL - 61 UR - https://doi.org/10.1016/0092-8674(90)90186-I DO - 10.1016/0092-8674(90)90186-I ID - Fearon1990 ER - TY - JOUR AU - Sakai, E. AU - Fukuyo, M. AU - Ohata, K. PY - 2016 DA - 2016// TI - Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway JO - Int J Cancer VL - 138 UR - https://doi.org/10.1002/ijc.29903 DO - 10.1002/ijc.29903 ID - Sakai2016 ER - TY - JOUR AU - Stevens, J. B. AU - Liu, G. AU - Abdallah, B. Y. PY - 2014 DA - 2014// TI - Unstable genomes elevate transcriptome dynamics JO - Int J Cancer VL - 134 UR - https://doi.org/10.1002/ijc.28531 DO - 10.1002/ijc.28531 ID - Stevens2014 ER - TY - JOUR AU - Grady, W. M. PY - 2004 DA - 2004// TI - Genomic instability and colon cancer JO - Cancer Metastasis Rev VL - 23 UR - https://doi.org/10.1023/A:1025861527711 DO - 10.1023/A:1025861527711 ID - Grady2004 ER - TY - JOUR AU - Boland, C. R. AU - Thibodeau, S. N. AU - Hamilton, S. R. PY - 1998 DA - 1998// TI - National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer JO - Cancer Res VL - 58 ID - Boland1998 ER - TY - JOUR AU - Barault, L. AU - Charon-Barra, C. AU - Jooste, V. PY - 2008 DA - 2008// TI - Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-08-1171 DO - 10.1158/0008-5472.CAN-08-1171 ID - Barault2008 ER - TY - JOUR AU - Weisenberger, D. J. AU - Siegmund, K. D. AU - Campan, M. PY - 2006 DA - 2006// TI - CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer JO - Nat Genet VL - 38 UR - https://doi.org/10.1038/ng1834 DO - 10.1038/ng1834 ID - Weisenberger2006 ER - TY - JOUR AU - Esteller, M. PY - 2008 DA - 2008// TI - Epigenetics in cancer JO - N Engl J Med VL - 358 UR - https://doi.org/10.1056/NEJMra072067 DO - 10.1056/NEJMra072067 ID - Esteller2008 ER - TY - JOUR AU - Peltomäki, P. PY - 2012 DA - 2012// TI - Mutations and epimutations in the origin of cancer JO - Exp Cell Res VL - 318 UR - https://doi.org/10.1016/j.yexcr.2011.12.001 DO - 10.1016/j.yexcr.2011.12.001 ID - Peltomäki2012 ER - TY - JOUR AU - Burotto, M. AU - Chiou, V. L. AU - Lee, J. M. PY - 2014 DA - 2014// TI - The MAPK pathway across different malignancies: a new perspective JO - Cancer VL - 120 UR - https://doi.org/10.1002/cncr.28864 DO - 10.1002/cncr.28864 ID - Burotto2014 ER - TY - JOUR AU - Bronte, G. AU - Silvestris, N. AU - Castiglia, M. PY - 2015 DA - 2015// TI - New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS? JO - Oncotarget. VL - 6 UR - https://doi.org/10.18632/oncotarget.4959 DO - 10.18632/oncotarget.4959 ID - Bronte2015 ER - TY - JOUR AU - Liu, J. AU - Hu, J. AU - Cheng, L. PY - 2016 DA - 2016// TI - Biomarkers predicting resistance to epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer with wild-type KRAS JO - Onco Targets Ther. VL - 9 UR - https://doi.org/10.2147/OTT.S86966 DO - 10.2147/OTT.S86966 ID - Liu2016 ER - TY - JOUR AU - Jorissen, R. N. AU - Walker, F. AU - Pouliot, N. PY - 2003 DA - 2003// TI - Epidermal growth factor receptor: mechanisms of activation and signaling JO - Exp Cell Res VL - 284 UR - https://doi.org/10.1016/S0014-4827(02)00098-8 DO - 10.1016/S0014-4827(02)00098-8 ID - Jorissen2003 ER - TY - JOUR AU - Markman, B. AU - Javier Ramos, F. AU - Capdevila, J. PY - 2010 DA - 2010// TI - EGFR and KRAS in colorectal cancer JO - Adv Clin Chem VL - 51 UR - https://doi.org/10.1016/S0065-2423(10)51004-7 DO - 10.1016/S0065-2423(10)51004-7 ID - Markman2010 ER - TY - JOUR AU - Bardelli, A. AU - Siena, S. PY - 2010 DA - 2010// TI - Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer JO - J Clin Oncol VL - 28 UR - https://doi.org/10.1200/JCO.2009.24.6116 DO - 10.1200/JCO.2009.24.6116 ID - Bardelli2010 ER - TY - JOUR AU - Yuan, Z. X. AU - Wang, X. Y. AU - Qin, Q. Y. PY - 2013 DA - 2013// TI - The prognostic role of BRAF mutation in metastatic colorectal cancer receiving anti-EGFR monoclonal antibodies: a meta-analysis JO - PLoS ONE VL - 8 UR - https://doi.org/10.1371/journal.pone.0065995 DO - 10.1371/journal.pone.0065995 ID - Yuan2013 ER - TY - JOUR AU - Qiu, L. X. AU - Mao, C. AU - Zhang, J. PY - 2010 DA - 2010// TI - Predictive and prognostic value of KRAS mutations in metastatic colorectal cancer patients treated with cetuximab: a meta-analysis of 22 studies JO - Eur J Cancer VL - 46 UR - https://doi.org/10.1016/j.ejca.2010.05.022 DO - 10.1016/j.ejca.2010.05.022 ID - Qiu2010 ER - TY - JOUR AU - Roth, A. D. AU - Tejpar, S. AU - Delorenzi, M. PY - 2010 DA - 2010// TI - Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial JO - J Clin Oncol VL - 28 UR - https://doi.org/10.1200/JCO.2009.23.3452 DO - 10.1200/JCO.2009.23.3452 ID - Roth2010 ER - TY - JOUR AU - Chen, J. AU - Guo, F. AU - Shi, X. PY - 2014 DA - 2014// TI - BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients JO - BMC Cancer VL - 14 UR - https://doi.org/10.1186/1471-2407-14-802 DO - 10.1186/1471-2407-14-802 ID - Chen2014 ER - TY - JOUR AU - Kadowaki, S. AU - Kakuta, M. AU - Takahashi, S. PY - 2015 DA - 2015// TI - Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer JO - World J Gastroenterol VL - 21 UR - https://doi.org/10.3748/wjg.v21.i4.1275 DO - 10.3748/wjg.v21.i4.1275 ID - Kadowaki2015 ER - TY - JOUR AU - Tol, J. AU - Nategaal, I. D. AU - Punt, C. J. A. PY - 2009 DA - 2009// TI - BRAF mutation in metastatic colorectal cancer JO - N Engl J Med VL - 361 UR - https://doi.org/10.1056/NEJMc0904160 DO - 10.1056/NEJMc0904160 ID - Tol2009 ER - TY - JOUR AU - Samowitz, W. S. AU - Sweeney, C. AU - Herrick, J. PY - 2005 DA - 2005// TI - Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-05-0404 DO - 10.1158/0008-5472.CAN-05-0404 ID - Samowitz2005 ER - TY - JOUR AU - Yokota, T. AU - Ura, T. AU - Shibata, N. PY - 2011 DA - 2011// TI - BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer JO - Br J Cancer VL - 104 UR - https://doi.org/10.1038/bjc.2011.19 DO - 10.1038/bjc.2011.19 ID - Yokota2011 ER - TY - JOUR AU - Therkildsen, C. AU - Bergmann, T. K. AU - Henrichsen-Schnack, T. PY - 2014 DA - 2014// TI - The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: a systematic review and meta-analysis JO - Acta Oncol VL - 53 UR - https://doi.org/10.3109/0284186X.2014.895036 DO - 10.3109/0284186X.2014.895036 ID - Therkildsen2014 ER - TY - JOUR AU - Zhu, L. AU - Dong, C. AU - Cao, Y. PY - 2016 DA - 2016// TI - Prognostic role of BRAF mutation in stage II/III colorectal cancer receiving curative resection and adjuvant chemotherapy: a meta-analysis based on randomized clinical trials JO - PLoS ONE VL - 1 UR - https://doi.org/10.1371/journal.pone.0154795 DO - 10.1371/journal.pone.0154795 ID - Zhu2016 ER - TY - JOUR AU - Palmieri, G. AU - Paliogiannis, P. AU - Scognamillo, F. PY - 2013 DA - 2013// TI - Colorectal cancer epidemiology in an area with a spontaneous screening program JO - Acta Medica Mediterr. VL - 29 ID - Palmieri2013 ER - TY - CHAP AU - Budroni, M. AU - Cesaraccio, R. AU - Pirino, D. ED - Forman, D. ED - Bray, F. ED - Brewster, D. H. ED - Gombe Mbalawa, G. ED - Kohler, B. ED - Pineros, M. ED - Steiliarova-Foucher, E. ED - Swaminatham, R. ED - Ferlay, J. PY - 2014 DA - 2014// TI - Cancer incidence in Sassari Province (2003–2007) BT - Cancer incidence in five continents PB - International Agency for Research on Cancer CY - Lyon ID - Budroni2014 ER - TY - JOUR AU - Palomba, G. AU - Colombino, M. AU - Contu, A. PY - 2012 DA - 2012// TI - Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia JO - J Transl Med. VL - 10 UR - https://doi.org/10.1186/1479-5876-10-178 DO - 10.1186/1479-5876-10-178 ID - Palomba2012 ER - TY - BOOK PY - 2010 DA - 2010// TI - TNM classification of malignant tumors PB - Wiley CY - Chichester ID - ref31 ER - TY - JOUR AU - Davies, H. AU - Bignell, G. R. AU - Cox, C. PY - 2002 DA - 2002// TI - Mutations of the BRAF gene in human cancer JO - Nature VL - 417 UR - https://doi.org/10.1038/nature00766 DO - 10.1038/nature00766 ID - Davies2002 ER - TY - JOUR AU - Casula, M. AU - Colombino, M. AU - Satta, M. P. PY - 2004 DA - 2004// TI - BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility JO - J Clin Oncol VL - 22 UR - https://doi.org/10.1200/JCO.2004.07.112 DO - 10.1200/JCO.2004.07.112 ID - Casula2004 ER - TY - JOUR AU - Paliogiannis, P. AU - Cossu, A. AU - Tanda, F. PY - 2014 DA - 2014// TI - KRAS mutational concordance between primary and metastatic colorectal adenocarcinoma JO - Oncol Lett. VL - 8 ID - Paliogiannis2014 ER - TY - JOUR AU - Loupakis, F. AU - Ruzzo, A. AU - Cremolini, C. PY - 2009 DA - 2009// TI - KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer JO - Br J Cancer VL - 101 UR - https://doi.org/10.1038/sj.bjc.6605177 DO - 10.1038/sj.bjc.6605177 ID - Loupakis2009 ER - TY - JOUR AU - Roock, W. AU - Claes, B. AU - Bernasconi, D. PY - 2010 DA - 2010// TI - Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis JO - Lancet Oncol. VL - 11 UR - https://doi.org/10.1016/S1470-2045(10)70130-3 DO - 10.1016/S1470-2045(10)70130-3 ID - Roock2010 ER - TY - JOUR AU - Heinemann, V. AU - Weikersthal, L. F. AU - Decker, T. PY - 2014 DA - 2014// TI - FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, Phase 3 trial JO - Lancet Oncol. VL - 15 UR - https://doi.org/10.1016/S1470-2045(14)70330-4 DO - 10.1016/S1470-2045(14)70330-4 ID - Heinemann2014 ER - TY - JOUR AU - Douillard, J. Y. AU - Oliner, K. S. AU - Siena, S. PY - 2013 DA - 2013// TI - Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer JO - N Engl J Med VL - 369 UR - https://doi.org/10.1056/NEJMoa1305275 DO - 10.1056/NEJMoa1305275 ID - Douillard2013 ER - TY - JOUR AU - Foltran, L. AU - Maglio, G. AU - Pella, N. PY - 2015 DA - 2015// TI - Prognostic role of KRAS, NRAS, BRAF and PIK3CA mutations in advanced colorectal cancer JO - Future Oncol. VL - 11 UR - https://doi.org/10.2217/fon.14.279 DO - 10.2217/fon.14.279 ID - Foltran2015 ER - TY - JOUR AU - Palomba, G. AU - Cossu, A. AU - Paliogiannis, P. PY - 2016 DA - 2016// TI - Prognostic role of KRAS mutations in Sardinian patients with colorectal carcinoma JO - Oncology letters. VL - 12 ID - Palomba2016 ER - TY - JOUR AU - Palomba, G. AU - Pisano, M. AU - Cossu, A. PY - 2005 DA - 2005// TI - Spectrum and prevalence of BRCA1 and BRCA2 germline mutations in Sardinian breast cancer patients through a hospital-based screening JO - Cancer VL - 104 UR - https://doi.org/10.1002/cncr.21298 DO - 10.1002/cncr.21298 ID - Palomba2005 ER - TY - JOUR AU - Palomba, G. AU - Loi, A. AU - Uras, A. PY - 2009 DA - 2009// TI - A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population JO - BMC Cancer VL - 9 UR - https://doi.org/10.1186/1471-2407-9-245 DO - 10.1186/1471-2407-9-245 ID - Palomba2009 ER - TY - JOUR AU - Casula, C. AU - Muggiano, A. AU - Cossu, A. PY - 2009 DA - 2009// TI - Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy JO - BMC Cancer VL - 9 UR - https://doi.org/10.1186/1471-2407-9-352 DO - 10.1186/1471-2407-9-352 ID - Casula2009 ER - TY - JOUR AU - Baldus, S. E. AU - Schaefer, K. L. AU - Engers, R. PY - 2010 DA - 2010// TI - Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases JO - Clin Cancer Res VL - 16 UR - https://doi.org/10.1158/1078-0432.CCR-09-2446 DO - 10.1158/1078-0432.CCR-09-2446 ID - Baldus2010 ER - TY - JOUR AU - Richman, S. D. AU - Seymour, M. T. AU - Chambers, P. PY - 2009 DA - 2009// TI - KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial JO - J Clin Oncol VL - 27 UR - https://doi.org/10.1200/JCO.2009.22.4295 DO - 10.1200/JCO.2009.22.4295 ID - Richman2009 ER - TY - JOUR AU - Souglakos, J. AU - Philips, J. AU - Wang, R. PY - 2009 DA - 2009// TI - Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer JO - Br J Cancer VL - 101 UR - https://doi.org/10.1038/sj.bjc.6605164 DO - 10.1038/sj.bjc.6605164 ID - Souglakos2009 ER - TY - JOUR AU - Tol, J. AU - Dijkstra, J. R. AU - Klomp, M. PY - 2010 DA - 2010// TI - Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab JO - Eur J Cancer VL - 46 UR - https://doi.org/10.1016/j.ejca.2010.03.036 DO - 10.1016/j.ejca.2010.03.036 ID - Tol2010 ER - TY - JOUR AU - Ogino, S. AU - Nosho, K. AU - Kirkner, G. J. PY - 2009 DA - 2009// TI - PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer JO - J Clin Oncol VL - 27 UR - https://doi.org/10.1200/JCO.2008.18.6544 DO - 10.1200/JCO.2008.18.6544 ID - Ogino2009 ER - TY - JOUR AU - Eklöf, V. AU - Wikberg, M. L. AU - Edin, S. PY - 2013 DA - 2013// TI - The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer JO - Br J Cancer VL - 108 UR - https://doi.org/10.1038/bjc.2013.212 DO - 10.1038/bjc.2013.212 ID - Eklöf2013 ER - TY - JOUR AU - Andreyev, H. J. AU - Norman, A. R. AU - Cunningham, D. PY - 2001 DA - 2001// TI - Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study JO - Br J Cancer VL - 85 UR - https://doi.org/10.1054/bjoc.2001.1964 DO - 10.1054/bjoc.2001.1964 ID - Andreyev2001 ER - TY - JOUR AU - Imamura, Y. AU - Morikawa, T. AU - Liao, X. PY - 2012 DA - 2012// TI - Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type JO - Clin Cancer Res VL - 18 UR - https://doi.org/10.1158/1078-0432.CCR-11-3210 DO - 10.1158/1078-0432.CCR-11-3210 ID - Imamura2012 ER - TY - JOUR AU - Pentheroudakis, G. AU - Kotoula, V. AU - Roock, W. PY - 2013 DA - 2013// TI - Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes JO - BMC Cancer VL - 13 UR - https://doi.org/10.1186/1471-2407-13-49 DO - 10.1186/1471-2407-13-49 ID - Pentheroudakis2013 ER - TY - JOUR AU - Ogino, S. AU - Nosho, K. AU - Kirkner, G. J. PY - 2009 DA - 2009// TI - CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer JO - Gut VL - 58 UR - https://doi.org/10.1136/gut.2008.155473 DO - 10.1136/gut.2008.155473 ID - Ogino2009 ER - TY - JOUR AU - Zlobec, I. AU - Kovac, M. AU - Erzberger, P. PY - 2010 DA - 2010// TI - Combined analysis of specific KRAS mutation, BRAF and microsatellite instability identifies prognostic subgroups of sporadic and hereditary colorectal cancer JO - Int J Cancer VL - 127 UR - https://doi.org/10.1002/ijc.25265 DO - 10.1002/ijc.25265 ID - Zlobec2010 ER - TY - JOUR AU - Winder, T. AU - Mündlein, A. AU - Rhomberg, S. PY - 2009 DA - 2009// TI - Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer JO - Oncol Rep VL - 21 UR - https://doi.org/10.3892/or_00000352 DO - 10.3892/or_00000352 ID - Winder2009 ER - TY - JOUR AU - Bazan, V. AU - Agnese, V. AU - Corsale, S. PY - 2005 DA - 2005// TI - Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell’Italia Meridionale (GOIM) prospective study JO - Ann Oncol VL - 16 UR - https://doi.org/10.1093/annonc/mdi908 DO - 10.1093/annonc/mdi908 ID - Bazan2005 ER - TY - JOUR AU - Ren, J. AU - Li, G. AU - Ge, J. PY - 2012 DA - 2012// TI - Is K-ras gene mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis JO - Dis Colon Rectum VL - 55 UR - https://doi.org/10.1097/DCR.0b013e318251d8d9 DO - 10.1097/DCR.0b013e318251d8d9 ID - Ren2012 ER -