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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Immunological profiling of patients with ulcerative colitis leads to identification of two inflammatory conditions and CD1a as a disease marker

Fig. 2

Immunological profiling leads to identification of distinct subgroups of UC patients. PBMC and serum were isolated from UC patients and subjected to flow cytometric analysis and ELISA, respectively. A Hierachically clustered heatmap based on frequencies of immune cells and serum levels of TGFß1, HGF and TARC. (linkage hierarchical cluster with euclidean distance). Simple clinical colitis activating index (SCCAI). B Boxplot analysis of concentrations of TARC, HGF and TGFß1 and plasma cells and TSLPR expressing CD11b+ macrophages and monocytes in dependence of diagnosis or treatment with TNFα-blockers and glucocorticoids. (UC patients n = 30, treated with TNFα blocker n = 16, Glucocorticoid n = 9, mesalazine n = 16, colectomized patients n = 5. C ROC curve for TARC (a) and TGFß1 (b) in differentiating group I+ II and III. TARC: 95% CI value 0.74–0.97, 18 cases treated with TNFα-blocker, 23 cases no treatment with TNFα-blockers; TGFß1: 95% CI value: 0.59–0.9, 18 cases treated with TNFα-blocker, 24 cases no treatment with TNFα-blockers

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