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Table 3 Individual and combined biomarker performance data for bladder cancer detection

From: A multiplex urinary immunoassay for bladder cancer detection: analysis of a Japanese cohort

Biomarker AUC 95 % CI No of correctly
predicted events
No of correctly
predicted nonevents
No of nonevents
predicted as events
No of events
Predicted as nonevents
Sensitivity Specificity PPV NPV
IL8 0.7039 0.6332–0.7746 151 43 24 60 0.716 0.642 0.863 0.417
MMP9 0.6315 0.5541–0.7090 104 51 16 107 0.493 0.761 0.867 0.323
SERPINA1 0.8027 0.7432–0.8622 163 49 18 48 0.773 0.731 0.901 0.505
ANG 0.7835 0.7241–0.8430 155 49 18 56 0.735 0.731 0.896 0.467
VEGFA 0.6488 0.5774–0.7202 89 54 13 122 0.422 0.806 0.873 0.307
CA9 0.7202 0.6550–0.7855 100 59 8 111 0.474 0.881 0.926 0.347
MMP10 0.6214 0.5433–0.6996 175 29 38 36 0.829 0.433 0.822 0.446
APOE 0.6298 0.5614–0.6983 83 63 4 128 0.393 0.940 0.954 0.330
SERPINE1 0.7989 0.7406–0.8571 141 54 13 70 0.668 0.806 0.916 0.435
SDC1 0.8161 0.7602–0.8719 145 58 9 66 0.687 0.866 0.942 0.468
10-Biomarker combination 0.8925 0.8507–0.9343 179 54 13 32 0.848 0.806 0.932 0.628
  1. AUC area under the curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value