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Table 1 Mean ± SD of body weight, serum concentrations of 25-OH vitamin D, calcium, liver enzymes and renal function parameters in the different study groups

From: The fibrolytic potentials of vitamin D and thymoquinone remedial therapies: insights from liver fibrosis established by CCl4 in rats

 

NC group

S-PC group

L-PC group

TQ group

VitD group

VitD/TQ group

Body weight (g)

231.57 ± 20.01

222.8 ± 18.71

201.97 ± 23.01a,b

228.42 ± 13.64c

230.1 ± 22.2c

229.5 ± 18.7c

25-OH Vitamin D (ng/ml)

46.19 ± 8.1

34.3 ± 4.9a

26.6 ± 6.7a,b

35.7 ± 9.5a,c

65.5 ± 9.1a,b,c,d

68.8 ± 8.7a,b,c,d

Calcium (mg/dL)

9.17 ± 0.51

9.1 ± 0.63

9.22 ± 0.44

9.24 ± 0.35

9.29 ± 0.42

9.23 ± 0.38

ALP (IU/L)

122.6 ± 11.2

211.4 ± 23.8a

315.7 ± 29.7a,b

170.8 ± 19.4a,b,c

167.3 ± 21.9a,b,c

131.6 ± 21.6b,c

ALT (U/L)

67 ± 5.4

133.3 ± 12.4a

271.2 ± 18.7a,b

88.7 ± 13.1b,c

75.4 ± 7.3b,c

69.3 ± 8.7b,c,d

AST (U/L)

92.4 ± 24.2

166.1 ± 28.8a

218.8 ± 26.7a

109.2 ± 21.6b,c

103 ± 19.8b,c

99 ± 11.9b,c

Creatinine (mg/dL)

0.22 ± 0.03

0.23 ± 0.05

0.2 ± 0.06

0.2 ± 0.03

0.19 ± 0.03

0.21 ± 0.05

Urea (mg/dL)

47.6 ± 5.1

49.1 ± 4.8

52.3 ± 4

51.6 ± 9.5

47.3 ± 5.8

49.1 ± 3.7

BUN (mg/dL)

22.2 ± 2.4

22.7 ± 2.8

24.4 ± 1.9

23.3 ± 2.4

22 ± 2.7

21.9 ± 2.4

  1. aP < 0.05 compared with normal ‘NC group
  2. bP < 0.05 compared with short positive control ‘S-PC group’
  3. cP < 0.05 compared with long positive control ‘L-PC group’
  4. dP < 0.05 compared with ‘TQ group’
  5. eP < 0.05 compared with ‘VitD group’