Fig. 1

Repeated exposure to TH2-inducing conditions induces IL-27 resistance. a ELISA analysis of IL-4 produced by healthy human CD4⁺ T cells subjected to two rounds of priming. b ELISA analysis of IL-4 produced by mouse CD4⁺ T cells primed as indicated. Error bars and statistical analyses are described in the “Methods” section. *P < 0.05, **P < 0.01, ***P < 0.001. The data represent more than three independent experiments with similar results