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Table 5 Ion channels genes most regulated in angiosarcoma vs controls

From: Ion channels expression and function are strongly modified in solid tumors and vascular malformations

Rank position in the top 250 (by value)

Gene identifier

Gene name

Adjusted p value*

log2 fold change

3th

KCNJ16

Potassium voltage-gated channel subfamily J member 16

0.0000003

+6.673

41th

CLCNKA

Chloride voltage-gated channel Ka

0.001

+3.516

52th

HCN2

Hyperpolarization activated cyclic nucleotide gated potassium channel 2

0.001

+2.099

53th

KCNQ2

Potassium voltage-gated channel subfamily Q member 2

0.001

+1.276

61th

FXYD4

FXYD domain containing ion transport regulator 4

0.0009

+6.247

75th

CRACR2B

Calcium release activated channel regulator 2B

0.002

+1.117

104th

AQP10

Aquaporin 10

0.004

+2.096

125th

KCNJ15

Potassium voltage-gated channel subfamily J member 15

0.004

+3.203

147th

KCNK12

Potassium two pore domain channel subfamily K member 12

0.004

+2.008

153th

FXYD2

FXYD domain containing ion transport regulator 2

0.005

+2.596

167th

KCNJ1

Potassium voltage-gated channel subfamily J member 1

0.01

+3.369

250th

AQP2

Aquaporin 2

0.01

+8.359

  1. * According to the Benjamini and Hochberg false discovery rate method
  2. Data from Geo dataset GSE44115, available at http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE44115)