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Table 4 Ion channels genes most regulated in bladder cancer vessels vs control vessels

From: Ion channels expression and function are strongly modified in solid tumors and vascular malformations

Rank position in the top 250 (by p value)

Gene identifier

Gene name

Adjusted p value*

log2 fold change

16th

KCNC4

Potassium voltage-gated channel subfamily C member 4

0.009

+0.507

42th

KCNG4

Potassium voltage-gated channel modifier subfamily G member 4

0.01

+0.415

75th

VDAC3

Voltage dependent anion channel 3

0.01

−1.511

90th

CRACR2B

Calcium release activated channel regulator 2B

0.01

+0.472

115th

KCNS2

Potassium voltage-gated channel modifier subfamily S member 2

0.01

+0.637

153th

SEC23B

Sec23 homolog B, coat complex II component (involved in vesicle trafficking)

0.01

−0.566

173th

CBARP

CACN Beta subunit associated regulatory protein

0.01

+0.627

218th

P2RX5

Purinergic receptor P2X 5 (ligand-gated ion channel)

0.01

+0.403

247th

SCN2B

Sodium voltage-gated channel beta subunit 2

0.02

+0.487

  1. * According to the Benjamini and Hochberg false discovery rate method
  2. Data from Geo dataset GSE41614, available at http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE41614)