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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Small cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2

Fig. 4

Inhibitory effect of miR-342 mimic on SCLC growth and ACh secretion. a, b Cell growth rates (based on cell count), were significantly reduced in both NCI-H82 and NCI-H345 cell lines transfected with the miR-342 mimic. A barely significant increase in cell growth was observed in the cells treated with the miR-342 inhibitor (96 h after treatment; n = 6). ACh secretion levels (e, f), and intracellular ACh content (c, d), were measured in both NCI-H82 and NCI-H345 cells after transfecting with either the miR-342 mimic or the miR-342 inhibitor 4 days post-transfection. (n = 3). Data (mean ± SE) were derived from three independent experiments (in triplicate) and normalized to total cell numbers. *P < 0.05, **P < 0.01

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