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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study

Fig. 6

Representative images of gastrocnemius muscle sections from non-PAD and PAD subjects stained for LC3, an autophagosome marker (red) and LAMP2, a lysosome marker (green). A In non-PAD, very little LC3 and LAMP2 staining is apparent. In PAD, rare fibers show co-localization of accumulated LC3 and LAMP2 (B), whereas the majority of fibers have elevated LC3 accumulation but no co-localization with LAMP2 (C). Arrows in the same column point to the same areas of LC3 accumulation in the center of the fiber with or without LAMP2 co-localization. Scale bar = 50μm

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