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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study

Fig. 5

Representative images of the variation of LC3 staining associated with cavities in SDH activity and mitochondrial COX-1 staining in PAD gastrocnemius muscle sections. First column shows succinate dehydrogenase (SDH) activity (dark fibers are type I, intermediate fibers are type IIa, and light fibers are type IIa/x), second column shows mitochondrial COX-1 protein (green), third column shows LC3 (red) and fourth column shows COX-1 and LC3 merged. Examples of normal fibers with no LC3 staining or COX-1 cavities (row A), punctate LC3 staining where a COX-1 cavitiy is forming (row B), elevated LC3 staining with low COX-1 staining (row C), LC3 accumulation in areas lacking COX-1 staining (row D), and LC3 plaque in the center of an SDH/COX1 cavity (COX-1; row E). Arrows within the same row point to areas of LC3 accumulation in same fiber. Scale bar = 100 µM

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