Decoding the usefulness of non-coding RNAs as breast cancer markers

Table 3 miRNA panels or single miRNAs proposed with a prognostic aim

	miRNA	Biological sample	Consequences	Refs.
miRNAs associated with positive outcome	miR-100	Tumor tissues	↑OS	[119]
	miR-29c			[120]
	miR-181d, -195-5p			[80]
	miR-128			[121]
	Let-7b, miR-205		↑RFS, OS	[122]
	miR-342-5p		↑RFS, OS	[123]
	miR-497		↓TNM, LNM	[124]
	miR-133a		↑RFS	[125]
	miR-30 family		↑ OS, RFS, DFS ↓Metastasis	[111–113]
	miR-206		↑OS ↓TNM, LNM	[126]
	miR-601		↓Metastasis ↑MFS	[102]
	miR-124		↑OS ↓TNM, LNM	[127]
	miR-138		↓TNM, LNM	[103]
	miR-190b		↑MFS, OS	[75]
	miR-200b		↓LNM	[128]
	miR-29b		↑DFS, OS	[129]
	miR-27a		↑DFS, OS	[130]
	miR-374b-5p, -218-5p, -126-3p	TNBC tissues	↑DFS, OS	[131]
	miR-155 -493	TNBC tissues	↑OS	[117]
	let-7c, miR-99a, -125b	Luminal A BC tissues	↑OS	[116]
miRNAs associated with negative outcome	miR-21	Tumor tissues	↑Grade, TNM, LNM, metastasis ↓DFS, RFS, OS	[107, 108]
	miR-210		↓OS, RFS, DFS, MFS ↑Grade	[109]
	miR-23a		↓RFS	[66]
	miR-423		↑Metastasis	[132]
	miR-9		↑Grade, metastasis, LR	[87]
	miR-187		↓DSS, RFS	[133]
	miR-155		↑TNM, grade, LNM ↓OS	[134]
	miR-221/222		↓MFS	[135]
	miR-421, -486, -503, -720, -1303		↓MFS	[136]
	miR-375		↑LR	[137]
	miR-548 family		↑LNM ↓MFS	[95]
	miR-146a-5p		↓OS	[80]
	miR-27b-3p	TNBC tissues	↑Metastasis ↓DSS	[138]
	miR-93		↑LNM, TNM, grade, Ki-67	[139]
	miR-21, -210, -221		↓DFS, OS	[140]
	miR-34b		↓DFS, OS	[141]
	miR-18b, -103, -107, -652	TNBC patients serum	↓OS, RFS.	[142]
	miR-200b	BC patients plasma	↓PFS, OS	[86]
	miR-202	BC patients serum	↓OS	[143]
	miR-10b-5p		↑TNM, grade, LNM	[144]
	miR-122		↓MFS, RFS	[78]
	miR-10b, -34a, -155		↑Metastasis	[145]

^↑Incresead; ^↓ Decreased
RFS relapse-free survival, TNM TNM classification of malignant tumours, MFS metastasis-free survival, LR local recurrence, DSS disease-specific survival

ISSN: 1479-5876