Decoding the usefulness of non-coding RNAs as breast cancer markers

Table 1 Non-circulating and circulating miRNAs for BC diagnosis

	miRNAs	Sample	Validation techniques	Samples size	Sensitivity	Specificity	AUC	Refs
Non-circulating miRNAs	↑miR-23a	BC tissues	qRT-PCR	76BC vs. 36 benign vs. 36 N	0.829	0.100	0.915	[66]
	↑miR-155, -21, -184, -518b, -572, -601, -622 ↓miR-125b		TaqMan qRT-PCR	24BC vs. 6 N	–	–	–	[67]
	↑miR-660-5p, ↓miR-99b-5p, -574-3p, -769-5p		SYBR Green qRT-PCR	56BC vs. 9 N 60BC vs. 11 N	–	–	–	[68]
Circulating miRNAs	↑miR-222	Serum	qRT-PCR	50BC vs. 50 N	0.74	0.60	0.671	[59]
	↑miR-16, -25, -222, -324-3p		TaqMan qRT-PCR	76BC vs. 76 N	0.921	0.934	0.928	[62]
	↑miR-145, -155, -382		qRT-PCR	61BC vs. 10 N	0.976	0.100	0.988	[69]
	↓miR-205		qRT-PCR	58BC vs. 93 N	0.862	0.828	0.84	[60]
	↑miR-199ª, -29c, -424		SdM-RT-PCR	76BC vs. 52 N	0.776	0.846	0.901	[63]
	↑miR-92a, miR-133a		qRT-PCR	132BC vs. 101 N	–	–	0.91	[70]
	↓miR-200c	Whole blood	qRT-PCR	57BC vs. 20 N	0.90	0.702	0.79	[71]
	↓miR-145 ↑miR-451	Plasma	TaqMan qRT-PCR	70BC vs. 50 N	0.900	0.920	0.931	[64]
	↑miR-127-3p, -148b, -376a, -376c, -409-3p, -652, -801		TaqMan qRT-PCR	120BC vs. 60 N	0.800	0.720	0.81	[65]
	↓miR-195		SYBR Green qRT-PCR	210BC vs. 102 N	0.69	0.892	0.859	[61]
	↑miR-16, -148a, -19b, -22a ↓Let-7d, let-7i, miR-103, -107		qRT-PCR	108BC vs. 88 N	0.91	0.49	0.81	[72]
	↑miR-505–5p ↑miR- 96–5p		qRT-PCR	114BC vs. 116 N	–	–	0.72 0.72	[73]

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