Fig. 4

Changes in CIK cell composition induced by MPA treatment. The influence of MPA treatment on receptor expression was analyzed for CD4, CD8, NKG2D and CD25. a The percentage of CD8⁺ cells decreased, whereas the proportion of CD4⁺ cells increased. b, c NKG2D was steadily expressed during short- (24 h) and intermediate-term (3 days) MPA treatment, only showing a reduction after long-term (7 days) MPA exposure. d CD25 expression clearly declined on T cells following long-term MPA exposure (p < 0.05) and on NK cells following intermediate- and long-term MPA treatment (p < 0.05). The most significant reduction in CD25 expression was shown for NK-like T cells after intermediate- and long-term MPA exposure. n = 6 independent experiments