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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Celecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells

Fig. 4

Celecoxib induces apoptosis and necrosis in KBM5 and KBM5-T315I cells. KBM5 and KBM5-T315I cells were treated with different concentrations of celecoxib for 24 h. A (a) Flow cytometry was used to test the apoptosis and necrosis. (b) The graph showed the percentage of Annexin V-/PI+ (necrosis) cells in left, and showed the Annexin V+/PI- (early apoptosis) and Annexin V+/PI+ (late apoptosis) cells in right. B (a) Hoechst 33342 staining was used to examine the apoptosis cells. (b) The graph showed that the percentage of cells with nuclear fragmentation. C Western blotting analysis showed cleaved caspase-3 fragment. Data were mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001

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