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Table 3 Endogenous and exogenous molecules predicted to be upstream regulators of the observed transcription changes

From: Proton-pump inhibitor omeprazole attenuates hyperoxia induced lung injury

IPA Entrez gene name z-score P of overlap
Upstream regulators predicted to be activated
 miR-155-5p (miRNAs w/seed UAAUGCU) microRNA 155-5p 2.611 2.08 × 10−3
 miR-16-5p (and other miRNAs w/seed AGCAGCA) microRNA 16-5p 2.425 2.58 × 10−2
 miR-30c-5p (and other miRNAs w/seed GUAAACA) microRNA 30c-5p 2.000 3.46 × 10−2
 MAPK9 mitogen-activated protein kinase 9 2.189 1.18 × 10−2
Upstream regulators predicted to be inhibited
 VEGF vascular endothelial growth factor (as a group) −2.229 1.23 × 10−3
 Gentamicin / −2.236 1.68 × 10−1
 STAT3 signal transducer and activator of transcription 3 −2.613 8.60 × 10−3
 EPAS1 endothelial PAS domain protein 1 −2.219 3.03 × 10−3
 NKX2-3 NK2 homeobox 3 −2.091 3.65 × 10−3
 ERG v-ets avian erythroblastosis virus E26 oncogene homologue −2.000 2.47 × 10−2
 OSM oncostatin M −2.687 7.06 × 10−4
 SP600125 / −2.236 5.61 × 10−2
 Lipopolysaccharide / −3.072 2.63 × 10−2