Table 3 Endogenous and exogenous molecules predicted to be upstream regulators of the observed transcription changes
From: Proton-pump inhibitor omeprazole attenuates hyperoxia induced lung injury
IPA | Entrez gene name | z-score | P of overlap |
|---|---|---|---|
Upstream regulators predicted to be activated | |||
 miR-155-5p (miRNAs w/seed UAAUGCU) | microRNA 155-5p | 2.611 | 2.08 × 10−3 |
 miR-16-5p (and other miRNAs w/seed AGCAGCA) | microRNA 16-5p | 2.425 | 2.58 × 10−2 |
 miR-30c-5p (and other miRNAs w/seed GUAAACA) | microRNA 30c-5p | 2.000 | 3.46 × 10−2 |
 MAPK9 | mitogen-activated protein kinase 9 | 2.189 | 1.18 × 10−2 |
Upstream regulators predicted to be inhibited | |||
 VEGF | vascular endothelial growth factor (as a group) | −2.229 | 1.23 × 10−3 |
 Gentamicin | / | −2.236 | 1.68 × 10−1 |
 STAT3 | signal transducer and activator of transcription 3 | −2.613 | 8.60 × 10−3 |
 EPAS1 | endothelial PAS domain protein 1 | −2.219 | 3.03 × 10−3 |
 NKX2-3 | NK2 homeobox 3 | −2.091 | 3.65 × 10−3 |
 ERG | v-ets avian erythroblastosis virus E26 oncogene homologue | −2.000 | 2.47 × 10−2 |
 OSM | oncostatin M | −2.687 | 7.06 × 10−4 |
 SP600125 | / | −2.236 | 5.61 × 10−2 |
 Lipopolysaccharide | / | −3.072 | 2.63 × 10−2 |