Fig. 1
From: Ockham’s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer
MET signaling pathway in IPF. Enhanced MET activation controls genetic programs leading to cell growth, invasiveness and protection from apoptosis. For both the biological and therapeutic implications of MET activation in myofibroblasts in FF, its KRAS-driven pro-proliferating activity can be separated from the PI3CA-related pro-invasive role. The activity of branching morphogenesis depends on STAT family members, mainly STAT3 (Giordano et al. [100]). STAT3 is known to contribute to lung damage in IPF onset and progression (Pedroza et al. FASEB J 2016; 30(1):129–4)