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Table 3 Muscle structure in both diaphragm and gastrocnemius muscles of all groups of mice of the 35-week cohort

From: Phenotypic and metabolic features of mouse diaphragm and gastrocnemius muscles in chronic lung carcinogenesis: influence of underlying emphysema

  Controls U E–U
Diaphragms
 Fiber type proportions
  Type I fibres (%) 8.1 (1.00) 8.2 (0.80) 7.7 (1.05)
  Type II fibres (%) 91.9 (1.00) 91.8 (0.80) 92.3 (1.05)
 Cross-sectional area
  Type I fibres (μm2) 257.9 (33.1) 221.7 (30.3)* 182.4 (12.8)***, §
  Type II fibres (μm2) 377.9 (30.1) 326.7 (47.6)* 258.8 (28.1)***, §§
Gastrocnemius
 Fiber type proportions
  Type I fibres (%) 22.7 (6.26) 24.0 (4.73) 20.5 (3.25)
  Type II fibres (%) 77.3 (6.26) 76.0 (4.73) 77.5 (3.25)
 Cross-sectional area    
  Type I fibres (μm2) 824.7 (155.2) 680.5 (67.6)* 609.8 (74.6)***
  Type II fibres (μm2) 835.3 (100.7) 721.9 (70.4)* 665.2 (80.0)***
  1. Variables are presented mean (standard deviation)
  2. U urethane, E–U elastase–urethane
  3. Statistical significance: * p ≤ 0.05 and *** p ≤ 0.001 between any of the experimental groups and the control mice
  4. §p ≤ 0.05 and §§p ≤ 0.01 between urethane and elastase-urethane groups of mice
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Journal of Translational Medicine

ISSN: 1479-5876

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