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Table 2 Muscle structure in both diaphragm and gastrocnemius muscles of mice of the 20-week cohort

From: Phenotypic and metabolic features of mouse diaphragm and gastrocnemius muscles in chronic lung carcinogenesis: influence of underlying emphysema

  Controls U E–U
Diaphragms
 Fiber type proportions
  Type I fibers (%) 8.9 (1.66) 9.5 (1.70) 8.3 (1.05)
  Type II fibers (%) 91.1 (1.66) 90.5 (1.70) 91.7 (1.05)
 Cross-sectional area
  Type I fibers (μm2) 342.7 (61.9) 235.7 (32.5)*** 155.3 (41.5)***, §
  Type II fibers (μm2) 473.2 (43.0) 328.2 (30.4)*** 230.6 (50.5)***, §§§
Gastrocnemius
 Fiber type proportions
  Type I fibers (%) 25.1 (7.28) 20.6 (4.82) 20.7 (6.74)
  Type II fibers (%) 74.9 (7.28) 79.4 (4.82) 79.3 (6.74)
 Cross-sectional area
  Type I fibers, (μm2) 746.6 (69.6) 504.5 (123.5)*** 491.4 (47.3)***
  Type II fibers, (μm2) 691.4 (65.7) 622.4 (61.8)* 568.5 (31.3)***
  1. Variables are presented as mean (standard deviation)
  2. U urethane, E–U elastase–urethane
  3. Statistical significance: * p ≤ 0.05 and *** p ≤ 0.001 between any of the experimental groups and the control mice
  4. §p ≤ 0.05 and §§§p ≤ 0.001 between urethane and elastase–urethane groups of mice