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Table 2 Muscle structure in both diaphragm and gastrocnemius muscles of mice of the 20-week cohort

From: Phenotypic and metabolic features of mouse diaphragm and gastrocnemius muscles in chronic lung carcinogenesis: influence of underlying emphysema

 

Controls

U

E–U

Diaphragms

 Fiber type proportions

  Type I fibers (%)

8.9 (1.66)

9.5 (1.70)

8.3 (1.05)

  Type II fibers (%)

91.1 (1.66)

90.5 (1.70)

91.7 (1.05)

 Cross-sectional area

  Type I fibers (μm2)

342.7 (61.9)

235.7 (32.5)***

155.3 (41.5)***, §

  Type II fibers (μm2)

473.2 (43.0)

328.2 (30.4)***

230.6 (50.5)***, §§§

Gastrocnemius

 Fiber type proportions

  Type I fibers (%)

25.1 (7.28)

20.6 (4.82)

20.7 (6.74)

  Type II fibers (%)

74.9 (7.28)

79.4 (4.82)

79.3 (6.74)

 Cross-sectional area

  Type I fibers, (μm2)

746.6 (69.6)

504.5 (123.5)***

491.4 (47.3)***

  Type II fibers, (μm2)

691.4 (65.7)

622.4 (61.8)*

568.5 (31.3)***

  1. Variables are presented as mean (standard deviation)
  2. U urethane, E–U elastase–urethane
  3. Statistical significance: * p ≤ 0.05 and *** p ≤ 0.001 between any of the experimental groups and the control mice
  4. §p ≤ 0.05 and §§§p ≤ 0.001 between urethane and elastase–urethane groups of mice
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Journal of Translational Medicine

ISSN: 1479-5876

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