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Table 5 Distribution of CD16A-48 and -158 haplotype frequencies in Italian LCTR and CRC patients, also distinguished for tumor grading

From: Role of KIR and CD16A genotypes in colorectal carcinoma genetic risk and clinical stage

CD16A Haplotype

LCTR HF (n = 61)

CRC HF (n = 52)

p valueb

Grade I–IIa (n = 31)

(af %)

P valueb

Grade III–IVa(n = 19)

(af %)

p valueb

48T-158G (48L158 V)

0.42623 ± 0.045824

0.432692 ± 0.049342

NS

45.2

NS

36.8

NS

48T-158T (48L158F)

0.409836 ± 0.047115

0.384615 ± 0.047437

NS

38.7

NS

39.5

NS

48A-158G (48H158 V)

0.049180 ± 0.01791

0.12500 ± 0.033282

0.05^

11.3

NS

15.8

0.037§

48G-158G (48R158 V)

0.114754 ± 0.026747

0.057692 ± 0.02222

NS

4.8

NS

7.9

NS

  1. § CD16-48A/158G OR 3.625
  2. ^ OR 2.7619
  3. aPatients with known staging included in the study (N = 50)
  4. bPearson X2 test: FCGR3A-48A/158G vs 48G/158G haplotype p = 0.0256