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Table 4 Distribution of CD16A-48 and -158 genetic polymorphisms in Italian local controls and CRC patients

From: Role of KIR and CD16A genotypes in colorectal carcinoma genetic risk and clinical stage

Genotypea

LCTRS (n = 61)

N (%)

CRC (n = 52)

N (%)

p value

OR

Grade I–II (n = 31)

N (%)

P value

Grade III–IV (n = 19)

N (%)

p value

OR

AA158

 CD16A-559T/T

5 (8.2)

4 (7.7)

NS

NS

2 (6.5)

NS

2 (10.5)

NS

NS

 CD16A -559G/T

40 (65.6)

32 (61.5)

NS

NS

20 (64.5)

NS

11 (57.9)

NS

NS

 CD16A -559G/G

16 (26.2)

16 (30.8)

NS

NS

9 (29.0)

NS

6 (31.6)

NS

NS

 CD16A -559GT + TT

47 (74.6)

36 (69.2)

NS

NS

22 (71.0)

NS

13 (68.4)

NS

NS

Allele

 CD16A -V158 (G)

72 (59.0)

64 (61.5)

NS

NS

38 (61.3)

NS

23 (60.5)

NS

NS

 CD16A -F158 (T)

50 (41.0)

40 (38.5)

NS

NS

24 (38.7)

NS

15 (39.5)

NS

NS

AA48

 

 CD16A -230A/G

0

1 (1.9)

NS

NS

0

NS

1 (5.3)

NS

NS

 CD16A -230G/T

10 (16.4)

5 (9.6)

NS

NS

2 (6.5)

NS

3 (15.8)

NS

NS

 CD16A -230G/G

2 (3.3)

0

NS

NS

0

NS

0

NS

NS

 CD16A -230T/T

43 (70.5)

34 (65.4)

NS

NS

21 (67.7)

NS

11 (57.9)

NS

NS

 CD16A -230A/Ta

6 (9.8)

12 (23.1)

0.07

NS

7 (22.6)

NS

5 (26.3)

NS

NS

Allele

 CD16A -H48 (A)a

6 (4.9)

13 (12.5)

0.05

2.761

7 (11.3)

NS

6 (15.8)

0.037

3.625

 CD16A -R48 (G)

14 (11.5)

6 (5.8)

NS

 

3 (4.8)

NS

3 (7.9)

NS

 

 CD16A -L48 (T)

102 (83.6)

85 (81.7)

NS

 

52 (83.9)

NS

29 (76.3)

NS

 
  1. aNo deviation from Hardy–Weinberg equilibrium was observed for the 559 and 230 allelic polymorphisms