Table 3 Summary of stathmin targeted treatment against human tumors
Publication | Cancer type | Molecule and mechanism | Activity | Notes |
|---|---|---|---|---|
Lu [27] | Pancreatic Cancer | Inhibitors of stathmin expression | mRNA downregulation | Knockdown of stathmin significantly reduces pancreatic cancer cell viability, colony formation. Furthermore, silence of stathmin retards pancreatic tumor growth in nude mice |
Machado-Neto [29] | Leukemia | siRNA | mRNA downregulation | Stathmin silencing in U937 and Namalwa leukemia cells reduces cell proliferation and clonogenicity |
Wu [60] | Nasopharyngeal carcinoma | siRNA | mRNA downregulation | The siRNA-mediated silencing of stathmin suppresses proliferation, invasion and metastasis, and induces apoptosis of nasopharyngeal carcinoma (NPC) cells |
Miceli [48] | Breast cancer | Ribozyme | mRNA downregulation | Adenovirus-mediated gene transfer of anti-stathmin ribozyme inhibits proliferation and clonogenicity in both ER-positive and ER-negative breast cancer cells |
Wang [77] | siRNA | mRNA downregulation | Knockdown of stathmin attenuates down-regulation of miR-101-mediated enhancement of cell growth and metastasis | |
Long [55] | shRNA | mRNA downregulation | Stathmin promoter-driving Aurora A shRNA adenoviral system has a potential use, which acts as adjuvant tumor-specific therapy method, in treatment of human breast carcinomas | |
Nie [3] | Lung cancer | siRNA | mRNA downregulation | Knockdown of stathmin in lung cancer cells results in a decrease in cellular proliferation and invasion |
Yuan [54] | Monoclonal antibodies | Protein downregulation | Monoclonal antibodies against stathmin inhibit proliferation of human lung carcinoma QG-56 cells and result in a significantly higher apoptosis rate | |
Hsieh [4] | Hepatoma | siRNA | mRNA downregulation | Silencing of stathmin expression via RNA interference suppresses invasion activity, while ectopic expression of stathmin enhances cell invasion and caused polyploidy of cells |
Wang [16] | Esophageal squamous cell carcinoma | shRNA-transfected | mRNA downregulation | Flow cytometry and mitotic index assays show that knockdown of stathmin in esophageal squamous cell carcinoma Eca109 and TE-1 cells leads leads to cell cycle arrest in G2/M phase |
Liu [13] | siRNA | mRNA downregulation | Knockdown of stathmin with siRNA impairs cell migration in esophageal squamous cell carcinoma KYSE30 and KYSE410 cells | |
Wang [14] | shRNA plasmid | mRNA downregulation | Down-regulation of stathmin significantly inhibits cell proliferation, cell migration in vitro, and tumorigenicity in vivo | |
Machado-Neto [62] | Myeloproliferative neoplasms | siRNA | mRNA downregulation | Silencing of stathmin significantly reduces cell proliferation and clonal growth, and increases apoptosis induced by ruxolitinib |
Mitra [86] | Retinoblastoma | Short interfering RNA | mRNA downregulation | Short interfering RNA-mediated transient stathmin down-regulation results in a marked inhibition of retinoblastoma cell proliferation and cell invasion in vitro |
He [33] | Endometrial carcinoma | siRNA | mRNA downregulation | Knockdown of stathmin inhibits endometrial carcinoma cell aggressive behaviors. |
Liu [25] | Gastric cancer | Antisense oligodeoxynucleotide | mRNA downregulation | Stathmin transfected by antisense oligodeoxynucleotide significantly inhibits proliferation of gastric cancer SGC 7901 cells |
Akhtar [91] | shRNA | mRNA downregulation | Stathmin shRNA-treated tumors are significantly regressed as compared with that of the tumor injected with non-silencing shRNA, proposing a potential use of local injection of lentivirus-delivered shRNA for the treatment of early localized human gastric carcinoma | |
Akhtar [90] | siRNA | mRNA downregulation | Lentiviral-mediated RNA interference targeting stathmin gene in human gastric cancer cells inhibits proliferation in vitro and tumor growth in vivo | |
Hemdan [36] | Bladder cancer | siRNA | mRNA downregulation | Growth and migration of urinary bladder cancer cell line T24 cells are significantly reduced by stathmin-siRNA |
Dong [89] | Glioma | siRNA | mRNA downregulation | When down-regulation of stathmin, cell viability of glioma is reduced, apoptosis rate increases and migration of vascular endothelial cells is suppressed significantly |