Publications | Cancer type | Cell lines | Tissue | Techniques | Notes |
---|---|---|---|---|---|
Nie [3] | Lung cancer | Yes | Yes | qRT-PCR, IHC | Overexpression of stathmin is a poor prognostic biomarker for non-small cell lung cancer |
Sun [11] | No | Yes | IHC, WB, qRT-PCR | Overexpression of stathmin correlates with shorter overall survival and progression-free survival in non-small cell lung cancer | |
Wang [15] | Esophageal carcinoma | No | Yes | IHC, ISH | Stathmin is associated with esophageal carcinoma (EC) development and progression and may be a good prognostic marker for patients with EC |
Wang [16] | Yes | Yes | IHC, WB | Stathmin is highly expressed in esophageal squamous cell carcinoma Eca109 and TE-1 cells | |
Liu [13] | Yes | Yes | 2-DE and IHC | Stathmin is overexpressed in esophageal squamous cell carcinoma (ESCC) tissues | |
Akhtar [12] | No | Yes | IHC, WB | Stathmin overexpression predicts a high risk for lymphatic metastatic recurrence in pN0 esophageal squamous cell carcinoma patients | |
Baquero [17] | Breast cancer | No | Yes | IHC | High stathmin expression predicts worse overall survival of breast cancer |
Watanabe [18] | Cholangiocarcinoma | Yes | Yes | IHC, WB | Stathmin correlates with shorter recurrence-free survival and overall survival in cholangiocarcinoma patients |
Hsieh [4] | Hepatocellular carcinoma | Yes | Yes | IHC, WB | Stathmin overexpression in hepatoma is associated with local invasion, early recurrence, and poor prognosis, and is an independent indicator for tumor recurrence |
Ahn [19] | Yes | Yes | IHC, WB | Stathmin and EF1α increase as multistep hepatocarcinogenesis progressed, showing the highest levels in hepatocellular carcinomas | |
Chen [20] | Yes | Yes | IHC, WB | Upregulation of E2F1 and stathmin are associated with worse outcomes in patients with hepatocellular carcinoma | |
Li [24] | Gastric cancer | Yes | Yes | IHC, WB | Stathmin is overexpressed in 103 post-operational gastric cancer specimens |
Liu [25] | Yes | Yes | IHC, WB | Stathmin is elevated in gastric cancer tissues, indicating a possible association between the stathmin and the disease occurrence | |
Batsaikhan [21] | No | Yes | IHC, ISH | Higher stathmin is significantly associated with gender-and poorly differentiated gastric adenocarcinoma | |
Kang [22] | Yes | Yes | IHC,WB, qRT-PCR | Stathmin is upregulated in gastric cancer cell lines and primary gastric adenocarcinomas, which is correlated with age, T stage and lymph node metastasis | |
Ke [23] | No | Yes | IHC, WB, qRT-PCR | Stathmin mRNA and protein in gastric cancer tissues are overexpressed, which correlates with Lauren’s classification, depth of invasion, lymph node metastases, and tumor node metastasis (TNM) stage | |
Lu [27] | Pancreatic cancer | Yes | Yes | IHC, WB | Stathmin is over-expressed in pancreatic cancer tissues and correlates with vascular emboli, tumor size, and overall survival |
Schimmack [28] | Pancreatic neuroendocrine neoplasm | Yes | Yes | IHC,WB, qRT-PCR | Stathmin mRNA and protein are overexpressed in pancreatic neuroendocrine neoplasm (pNENs) and correlate with pNEN tumor extension, size, and Ki67 expression |
Li [59] | Yes | Yes | IHC, WB | Stathmin is overexpressed to a large extent in pancreatic cancer tissues and cell lines | |
Machado-Neto [29] | Myelodysplastic syndromes | Yes | Yes | IHC, WB | Higher stathmin level is observed in proliferating hematopoietic cells, high-risk myelodysplastic syndromes (MDS) and acute leukemia cells |
Hsu [30] | Nasopharyngeal carcinoma | Yes | Yes | IHC, WB | Higher stathmin expression is correlated with advanced age higher T stage and overall clinical stage |
Birnie [31] | Malignant pleural mesothelioma | Yes | No | IHC, WB | Stathmin expression is higher in malignant pleural mesothelioma cell lines when compared with primary mesothelial cell controls |
Howitt [32] | Cervical carcinomas | No | Yes | IHC | Stathmin is overexpressed in virtually all cervical carcinomas and cervical intraepithelial neoplasias 3 (CIN3) lesions |
He [33] | Endometrial carcinoma | Yes | Yes | IHC | Stathmin is up-regulated in endometrial carcinoma (EC), and elevated stathmin is correlated positively with tumor stage and lymph node metastasis |
Wik [34] | Yes | Yes | IHC, FISH, FCM, SNP | High p-stathmin(S38) level is associated with poor prognosis, independent of other features. | |
Bhagirath [37] | Bladder urothelial carcinoma | No | No | ELISA, qRT-PCR | The urinary level of serum stathmin concentration shows a specific increase in patients with urothelial carcinoma of the bladder as compared to the controls |
Wosnitzer [35] | No | Yes | Immunophenotype analysis | Increased total tau (cytoplasmic and nuclear) and stathmin before intravesical taxane therapy is significantly associated with decreased recurrence-free survival | |
Hemdan [36] | No | Yes | IHC,WB | High stathmin expression correlates to shorter disease-specific survival hazard ratio, elevated p53 and Ki67-protein levels | |
Tan [38] | Colorectal cancer | Yes | Yes | 2-D DIGE | Stathmin is found to be highly up-regulated in colorectal cancer E1 cells as compared to HCT-116 cells |
Marie [39] | Glioblastoma | Yes | Yes | qRT-PCR | Stathmin expression is significantly increased in malignant diffusely infiltrative astrocytomas compared with pilocytic astrocytoma |