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Table 2 Merck index active ingredient patent listing for the 48 cardiovascular drugs

From: Could patents interfere with the development of a cardiovascular polypill?

INN Latest patent grant year provided International INPADOC family application date range Patent numbers provided
Olmesartan 1997 1992–2011 EP503785, US5616599
Valsartan 1995 1991–2010 EP443983, US5399578
Candesartan 1993 1991–2006 EP459136, US5196444
Eprosartan 1993 1990–2001 EP403159, US5185351
Irbesartan 1993 1990–1999 WO9114679, US5270317
Atorvastatin 1993 1990–2007 EP409281, US5273995
Rosuvastatin 1993 1992–2003 EP521471, US5260440
Losartan 1992 1987–1999 EP253310, US5138069
Telmisartan 1992 1991–2011 EP502314
Fosinopril 1991 1988–1995 EP 304063, US5011930
Pitavastatin 1991 1988–1995 EP304063, US5011930
Trandolapril 1990 1981–1994 EP84164, US4933361
Clopidogrel 1989 1982–1998 EP99802, US4529596, EP281459, US4847265
Fluvastatin 1988 1983–1995 WO8402131, US4739073
Nebivolol 1987 1984–2004 EP145067, US4654362
Ramipril 1986 1982–1994 EP79022, US4587258
Amlodipine 1986 1983–1998 EP89167, US4572909
Perindopril 1985 1979–1993 EP49658, US4508729
Carvedilol 1985 1978–1994 DE2815926, US4503067
Eplerenone 1985 1984–2004 EP122232, US4559332
Simvastatin 1984 1980–1994 EP33538, US4444784
Benazepril 1983 1982–1993 EP72352, US4410520
Enalapril 1983 1979–1998 EP12401, US4374829
Lisinopril 1983 1979–1998 EP12401, US4374829
Quinapril 1982 1981–1996 EP49605, US4344949
Pravastatin 1982 1980–1996 DE3122499, US4346227
Felodipine 1981 1978–1994 EP7293, US4264611
Bisoprolol 1981 1976–1993 BE859425, US4258062
Lovastatin 1980 1978–1998 US4231938
Torasemide 1977 1974–1994 DE2516025, US4018929
Metoprolol 1976 1932–1977 DE2106209, US3998790
Nadolol 1976 1971–1979 DE2258995, US3935267, DE2421549
Nimodipine 1974 1971–1977 DE2117571, US3799934
Acebutolol 1974 1967–1974 ZA6808345, US3857952
Atenolol 1974 1969–1975 DE2007751, US3663607, US3836671
Bumetanide 1974 1968–1974 DE1964503, DE1964504, US3806534
Indapamide 1971 1968–1969 FR2003311, US3565911
Propranolol 1970 1962–1967 BE640312, BE640313, US3337628, US3520919
Nifedipine 1969 1967–1969 ZA6801482, US3485847
Amiloride 1967 1962–1981 BE639386, US3313813
Metolazone 1967 1966–1967 US3360518
Acetylsalicylic acid (aspirin) 1966 1959–1964 DE236196, US2890240, US3235583
Hydrochlorothiazide 1964 1962–1965 US3025292, US3163645, DE1163332, US3164588, US3043840
Triamterene 1963 1960–1964 US3081230
Chlorthalidone 1962 1957–1962 US3055904
Furosemide 1962 1959–1964 DE1122541, US305888
Spironolactone 1961 1960–1961 US3013012
Chlorothiazide 1957 1957 US2809194