Journal of Translational Medicine

Table 2 Merck index active ingredient patent listing for the 48 cardiovascular drugs

From: Could patents interfere with the development of a cardiovascular polypill?

INN	Latest patent grant year provided	International INPADOC family application date range	Patent numbers provided
Olmesartan	1997	1992–2011	EP503785, US5616599
Valsartan	1995	1991–2010	EP443983, US5399578
Candesartan	1993	1991–2006	EP459136, US5196444
Eprosartan	1993	1990–2001	EP403159, US5185351
Irbesartan	1993	1990–1999	WO9114679, US5270317
Atorvastatin	1993	1990–2007	EP409281, US5273995
Rosuvastatin	1993	1992–2003	EP521471, US5260440
Losartan	1992	1987–1999	EP253310, US5138069
Telmisartan	1992	1991–2011	EP502314
Fosinopril	1991	1988–1995	EP 304063, US5011930
Pitavastatin	1991	1988–1995	EP304063, US5011930
Trandolapril	1990	1981–1994	EP84164, US4933361
Clopidogrel	1989	1982–1998	EP99802, US4529596, EP281459, US4847265
Fluvastatin	1988	1983–1995	WO8402131, US4739073
Nebivolol	1987	1984–2004	EP145067, US4654362
Ramipril	1986	1982–1994	EP79022, US4587258
Amlodipine	1986	1983–1998	EP89167, US4572909
Perindopril	1985	1979–1993	EP49658, US4508729
Carvedilol	1985	1978–1994	DE2815926, US4503067
Eplerenone	1985	1984–2004	EP122232, US4559332
Simvastatin	1984	1980–1994	EP33538, US4444784
Benazepril	1983	1982–1993	EP72352, US4410520
Enalapril	1983	1979–1998	EP12401, US4374829
Lisinopril	1983	1979–1998	EP12401, US4374829
Quinapril	1982	1981–1996	EP49605, US4344949
Pravastatin	1982	1980–1996	DE3122499, US4346227
Felodipine	1981	1978–1994	EP7293, US4264611
Bisoprolol	1981	1976–1993	BE859425, US4258062
Lovastatin	1980	1978–1998	US4231938
Torasemide	1977	1974–1994	DE2516025, US4018929
Metoprolol	1976	1932–1977	DE2106209, US3998790
Nadolol	1976	1971–1979	DE2258995, US3935267, DE2421549
Nimodipine	1974	1971–1977	DE2117571, US3799934
Acebutolol	1974	1967–1974	ZA6808345, US3857952
Atenolol	1974	1969–1975	DE2007751, US3663607, US3836671
Bumetanide	1974	1968–1974	DE1964503, DE1964504, US3806534
Indapamide	1971	1968–1969	FR2003311, US3565911
Propranolol	1970	1962–1967	BE640312, BE640313, US3337628, US3520919
Nifedipine	1969	1967–1969	ZA6801482, US3485847
Amiloride	1967	1962–1981	BE639386, US3313813
Metolazone	1967	1966–1967	US3360518
Acetylsalicylic acid (aspirin)	1966	1959–1964	DE236196, US2890240, US3235583
Hydrochlorothiazide	1964	1962–1965	US3025292, US3163645, DE1163332, US3164588, US3043840
Triamterene	1963	1960–1964	US3081230
Chlorthalidone	1962	1957–1962	US3055904
Furosemide	1962	1959–1964	DE1122541, US305888
Spironolactone	1961	1960–1961	US3013012
Chlorothiazide	1957	1957	US2809194

Back to article page

ISSN: 1479-5876

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com