Skip to main content

Table 1 The 48 cardiovascular drugs categorized by type of patent protection and country

From: Could patents interfere with the development of a cardiovascular polypill?

Drug United States Canada Other countries
Patentsa Patentsa Patentsb
Co-formulation Compound Formulation Method Process Co-formulation Compound Formulation Method Process Co-formulation Compound Formulation Method Process
Acebutolol                
Acetylsalicylic acid (aspirin)    X X     X X     16 16  
Amiloride                
Amlodipine X   X X X X      63 1 4 7 4
Atenolol                
Atorvastatin X   X X X X   X X X 50 4 53 39 39
Benazepril X               
Bisoprolol                
Bumetanide                
Candesartan X X   X     X X X 1   4 10 9
Carvedilol    X X X    X X X    22 29 13
Chlorothiazide                
Chlorthalidone X      X      31     
Clopidogrel    X   X    X   X   11 44   44
Enalapril             3    
Eplerenone X   X X   X   X X   25 3 25 25  
Eprosartan X   X X X X   X X X 7 6 37 42 37
Felodipine                
Fluvastatin    X      X      36   
Fosinopril             2    
Furosemide                
Hydrochlorothiazide X      X      60     
Indapamide X      X      37     
Irbesartan X   X    X   X    23 8 23   
Lisinopril             3    
Losartan    X   X        2    
Lovastatin X   X      X    13 1 12 12  
Metolazone                
Metoprolol                
Nadolol                
Nebivolol    X      X     1 31 4  
Nifedipine                
Nimodipine                
Olmesartan X X X X X X   X    29 8 24 8 8
Perindopril    X X X X   X X X 18   37 18  
Pitavastatin X   X X X    X X X 13 2 17 17 10
Pravastatin     X      X    1   8  
Propranolol    X X     X X     10 10  
Quinapril    X X    X      1 3 3  
Ramipril X    X   X    X   34   34 35  
Rosuvastatin   X X X     X X   6 50 33   
Simvastatin X      X      19     
Spironolactone                
Telmisartan X X X X X X   X X X 49 6 35 17 36
Torasemide                
Trandolapril X    X    X    X 3    2  
Triamterene                
Valsartan X X X X   X   X X   42 7 36 36  
Total 18 5 20 18 10 14 2 18 14 9 523 120 536 338 200
  All countries           
Grand totals 555 127 574 370 219      
  1. aA “X” means that at least one patent was found fitting into this category on the national patent register. The underline “X” denotes at least one patent was found in the INPADOC and/or Derwent patent family, but current legal status is unknown
  2. bThe numbers below indicate the number of jurisdictions (countries or regional agreements) covered by the patents in the INPADOC and Derwent patent families. Current legal status of these patents is unknown