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Table 1 The 48 cardiovascular drugs categorized by type of patent protection and country

From: Could patents interfere with the development of a cardiovascular polypill?

Drug

United States

Canada

Other countries

Patentsa

Patentsa

Patentsb

Co-formulation

Compound

Formulation

Method

Process

Co-formulation

Compound

Formulation

Method

Process

Co-formulation

Compound

Formulation

Method

Process

Acebutolol

               

Acetylsalicylic acid (aspirin)

  

X

X

   

X

X

   

16

16

 

Amiloride

               

Amlodipine

X

 

X

X

X

X

    

63

1

4

7

4

Atenolol

               

Atorvastatin

X

 

X

X

X

X

 

X

X

X

50

4

53

39

39

Benazepril

X

              

Bisoprolol

               

Bumetanide

               

Candesartan

X

X

 

X

   

X

X

X

1

 

4

10

9

Carvedilol

  

X

X

X

  

X

X

X

  

22

29

13

Chlorothiazide

               

Chlorthalidone

X

    

X

    

31

    

Clopidogrel

  

X

 

X

  

X

 

X

 

11

44

 

44

Enalapril

           

3

   

Eplerenone

X

 

X

X

 

X

 

X

X

 

25

3

25

25

 

Eprosartan

X

 

X

X

X

X

 

X

X

X

7

6

37

42

37

Felodipine

               

Fluvastatin

  

X

    

X

    

36

  

Fosinopril

           

2

   

Furosemide

               

Hydrochlorothiazide

X

    

X

    

60

    

Indapamide

X

    

X

    

37

    

Irbesartan

X

 

X

  

X

 

X

  

23

8

23

  

Lisinopril

           

3

   

Losartan

  

X

 

X

      

2

   

Lovastatin

X

 

X

    

X

  

13

1

12

12

 

Metolazone

               

Metoprolol

               

Nadolol

               

Nebivolol

  

X

    

X

   

1

31

4

 

Nifedipine

               

Nimodipine

               

Olmesartan

X

X

X

X

X

X

 

X

  

29

8

24

8

8

Perindopril

  

X

X

X

X

 

X

X

X

18

 

37

18

 

Pitavastatin

X

 

X

X

X

  

X

X

X

13

2

17

17

10

Pravastatin

   

X

    

X

  

1

 

8

 

Propranolol

  

X

X

   

X

X

   

10

10

 

Quinapril

  

X

X

  

X

    

1

3

3

 

Ramipril

X

  

X

 

X

  

X

 

34

 

34

35

 

Rosuvastatin

 

X

X

X

   

X

X

 

6

50

33

  

Simvastatin

X

    

X

    

19

    

Spironolactone

               

Telmisartan

X

X

X

X

X

X

 

X

X

X

49

6

35

17

36

Torasemide

               

Trandolapril

X

  

X

  

X

  

X

3

  

2

 

Triamterene

               

Valsartan

X

X

X

X

 

X

 

X

X

 

42

7

36

36

 

Total

18

5

20

18

10

14

2

18

14

9

523

120

536

338

200

 

All countries

          

Grand totals

555

127

574

370

219

     
  1. aA “X” means that at least one patent was found fitting into this category on the national patent register. The underline “X” denotes at least one patent was found in the INPADOC and/or Derwent patent family, but current legal status is unknown
  2. bThe numbers below indicate the number of jurisdictions (countries or regional agreements) covered by the patents in the INPADOC and Derwent patent families. Current legal status of these patents is unknown