Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

Table 1 Univariate analysis of MBL, properdin, C3, C3d and C5b-9

Plasma concentration	At start hemodialysis	At end hemodialysis	P-value^a	Controls	P-value^b
MBL	879 (255–1572)	821 (319–1477)	0.005	784 (277–1449)	0.9
Properdin	16.8 (13.6–22.4)	18.0 (14.2–23.8)	0.01	13.0 (10.8–14.7)	<0.0001
C3d	7.3 (5.6–10.1)	10.3 (7.4–16.9)	<0.0001	2.7 (2.3–3.4)	<0.0001
C5b-9	214 (166–419)	253 (187–487)	<0.0001	141 (107–262)	<0.0001

Plasma concentration	No CV-event	CV-event	P-value^c
MBL	1074 (428–1722)	464 (111–1102)	0.006
Properdin	18.6 (14.0–24.0)	17.3 (15.1–23.4)	0.8
C3d	10.3 (7.3–16.7)	10.8 (7.4–17.2)	0.8
C3d/C3	8.2 (6.3–13.7)	8.6 (6.0–15.6)	0.5
C3	1.28 (1.08–1.53)	1.32 (1.14–1.55)	0.6
C5b-9	249 (182–513)	266 (194–473)	0.8

% CV event-free survival	Low level (%)	High level (%)	P-value^d
MBL^e	42.30	74.10	0.003
MBL^f	48.50	74.30	0.02
Properdin^e	65.40	74.10	0.6
C3d^g	67.50	66.70	0.8
C3d/C3^g	67.50	66.70	0.9
C3^g	68.80	63.00	0.7
C5b-9^g	67.50	69.20	0.4

Values are expressed as median (interquartile range). Increased levels of MBL, properdin, C3d and C5b-9 were found at the end of hemodialysis compared with at the start of hemodialysis and controls. MBL was significantly lower in hemodialysis patients suffering from a cardiovascular event. An association was found between MBL and the cumulative incidence of a cardiovascular event
Italic values used to show which statistical testing was significant (below 0.05)
CV-event cardiovascular event; MBL mannose-binding lectin
^a Wilcoxon signed-rank test, at start hemodialysis vs. at end hemodialysis. All P-values are two-sided
^b Mann–Whitney test, at end hemodialysis vs. controls. All P-values are two-sided
^c Mann–Whitney test. All P-values are two-sided
^d Log-rank test
^e Split by lowest 25 %
^f Split by 400 ng/mL
^g Split by highest 25 %

ISSN: 1479-5876