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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients

Fig. 2

Infiltration patterns by immune cells in melanoma metastases. Representative sections are shown for the ac, as well as for the heterogeneous infiltration pattern observed in two samples from NB group. a schematic drawing for the T cell infiltration is shown for each pattern. IHC stainings for all Pattern type are shown for: PanMel or MCSP (tumor cells), CD3 (T cells), CD8 (CTLs), CD20 (B cells), CD163 (macrophages). The positive cells for all stainings are shown in red on the IHC sections. Zoom in images are shown for the samples MEL 26 (b), MEL 2 (c) and MEL 21 (heterogeneous pattern). This illustrates the geographical association of T cells, B cells and macrophages. Additionally the vWF staining (blood vessels) is shown for MEL 17—a in order to illustrate the exclusive perivascular T cell localization. Staining for HLA class I and TAP-1 are shown for Pattern B and Heterogeneous Pattern. Loss of TAP-1 expression by tumor cells is illustrated for samples MEL 15 and MEL 26 (b) from 2 NB patients. Loss of HLA class I expression is shown for MEL 21 (heterogeneous pattern)

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