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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients

Fig. 1

Gene expression analysis for patients with DB and patients with NB from immunotherapy by Ipilimumab ±DC vaccination. a Supervised hierarchical clustering of patients with high clinical benefit vs. no clinical benefit using the list of 325 genes that were differentially expressed between these two groups (FDR <0.05). On the right, the list of genes with immune-relevant functions (64 with an FDR <0.05 including 25 with an FDR <0.01). b PFS of the 12 patients analyzed in a. c OS of the 12 patients analyzed in a. d CRP and LDH baseline levels for the five patients in the DB group vs. the seven patients in the NB group; Normal range for CRP <5 mg/L and for LDH 313–618 U/L, the normal range are highlighted in transparent green color. e Timeline for the DB patient's clinical course during Ipi-based immunotherapy. f Differential DNA methylation analysis of all annotated methylation cores (intron, exon and promoter regions) between DB and NB. 83 cores associated with 68 genes were differentially methylated (FDR <0.001). Forty-nine of these cores were located in introns, 14 in exons and 20 in promoter regions

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